The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

Mitochondrial dysfunction underlies many heritable diseases, acquired pathologies, and aging-related declines in health. Szeto–Schiller (SS) peptides comprise a class of amphipathic tetrapeptides that are efficacious toward a wide array of mitochondrial disorders and are believed to target mitochond...

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Detalles Bibliográficos
Autores principales: Mitchell, Wayne, Ng, Emily A., Tamucci, Jeffrey D., Boyd, Kevin J., Sathappa, Murugappan, Coscia, Adrian, Pan, Meixia, Han, Xianlin, Eddy, Nicholas A., May, Eric R., Szeto, Hazel H., Alder, Nathan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247319/
https://www.ncbi.nlm.nih.gov/pubmed/32273339
http://dx.doi.org/10.1074/jbc.RA119.012094

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