Cargando…
Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease
Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanism...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247326/ https://www.ncbi.nlm.nih.gov/pubmed/32370194 http://dx.doi.org/10.3390/ijms21093226 |
_version_ | 1783538132003586048 |
---|---|
author | Martins, Gabriela Lopes Duarte, Rita Carolina Figueiredo Mukhamedyarov, Marat Alexandrovich Palotás, András Ferreira, Cláudia Natália Reis, Helton José |
author_facet | Martins, Gabriela Lopes Duarte, Rita Carolina Figueiredo Mukhamedyarov, Marat Alexandrovich Palotás, András Ferreira, Cláudia Natália Reis, Helton José |
author_sort | Martins, Gabriela Lopes |
collection | PubMed |
description | Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed. |
format | Online Article Text |
id | pubmed-7247326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72473262020-06-10 Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease Martins, Gabriela Lopes Duarte, Rita Carolina Figueiredo Mukhamedyarov, Marat Alexandrovich Palotás, András Ferreira, Cláudia Natália Reis, Helton José Int J Mol Sci Review Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed. MDPI 2020-05-02 /pmc/articles/PMC7247326/ /pubmed/32370194 http://dx.doi.org/10.3390/ijms21093226 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martins, Gabriela Lopes Duarte, Rita Carolina Figueiredo Mukhamedyarov, Marat Alexandrovich Palotás, András Ferreira, Cláudia Natália Reis, Helton José Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease |
title | Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease |
title_full | Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease |
title_fullStr | Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease |
title_full_unstemmed | Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease |
title_short | Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease |
title_sort | inflammatory and infectious processes serve as links between atrial fibrillation and alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247326/ https://www.ncbi.nlm.nih.gov/pubmed/32370194 http://dx.doi.org/10.3390/ijms21093226 |
work_keys_str_mv | AT martinsgabrielalopes inflammatoryandinfectiousprocessesserveaslinksbetweenatrialfibrillationandalzheimersdisease AT duarteritacarolinafigueiredo inflammatoryandinfectiousprocessesserveaslinksbetweenatrialfibrillationandalzheimersdisease AT mukhamedyarovmaratalexandrovich inflammatoryandinfectiousprocessesserveaslinksbetweenatrialfibrillationandalzheimersdisease AT palotasandras inflammatoryandinfectiousprocessesserveaslinksbetweenatrialfibrillationandalzheimersdisease AT ferreiraclaudianatalia inflammatoryandinfectiousprocessesserveaslinksbetweenatrialfibrillationandalzheimersdisease AT reisheltonjose inflammatoryandinfectiousprocessesserveaslinksbetweenatrialfibrillationandalzheimersdisease |