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Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease

Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanism...

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Autores principales: Martins, Gabriela Lopes, Duarte, Rita Carolina Figueiredo, Mukhamedyarov, Marat Alexandrovich, Palotás, András, Ferreira, Cláudia Natália, Reis, Helton José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247326/
https://www.ncbi.nlm.nih.gov/pubmed/32370194
http://dx.doi.org/10.3390/ijms21093226
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author Martins, Gabriela Lopes
Duarte, Rita Carolina Figueiredo
Mukhamedyarov, Marat Alexandrovich
Palotás, András
Ferreira, Cláudia Natália
Reis, Helton José
author_facet Martins, Gabriela Lopes
Duarte, Rita Carolina Figueiredo
Mukhamedyarov, Marat Alexandrovich
Palotás, András
Ferreira, Cláudia Natália
Reis, Helton José
author_sort Martins, Gabriela Lopes
collection PubMed
description Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed.
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spelling pubmed-72473262020-06-10 Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease Martins, Gabriela Lopes Duarte, Rita Carolina Figueiredo Mukhamedyarov, Marat Alexandrovich Palotás, András Ferreira, Cláudia Natália Reis, Helton José Int J Mol Sci Review Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed. MDPI 2020-05-02 /pmc/articles/PMC7247326/ /pubmed/32370194 http://dx.doi.org/10.3390/ijms21093226 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martins, Gabriela Lopes
Duarte, Rita Carolina Figueiredo
Mukhamedyarov, Marat Alexandrovich
Palotás, András
Ferreira, Cláudia Natália
Reis, Helton José
Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease
title Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease
title_full Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease
title_fullStr Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease
title_full_unstemmed Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease
title_short Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease
title_sort inflammatory and infectious processes serve as links between atrial fibrillation and alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247326/
https://www.ncbi.nlm.nih.gov/pubmed/32370194
http://dx.doi.org/10.3390/ijms21093226
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