Cargando…

Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin

Statin-induced autoimmune necrotising myopathy causes a severe progressive muscle weakness even when the statins are discontinued. First-line treatment is usually with high dose steroids followed by immunosuppressants, but this is often ineffective and there is a high risk of side effects. We descri...

Descripción completa

Detalles Bibliográficos
Autores principales: Güngör, Cansu, Wieshmann, Udo Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247403/
https://www.ncbi.nlm.nih.gov/pubmed/32444443
http://dx.doi.org/10.1136/bcr-2020-234805
_version_ 1783538148434771968
author Güngör, Cansu
Wieshmann, Udo Carl
author_facet Güngör, Cansu
Wieshmann, Udo Carl
author_sort Güngör, Cansu
collection PubMed
description Statin-induced autoimmune necrotising myopathy causes a severe progressive muscle weakness even when the statins are discontinued. First-line treatment is usually with high dose steroids followed by immunosuppressants, but this is often ineffective and there is a high risk of side effects. We describe a diabetic patient who had a very severe statin-induced autoimmune myopathy. He made a full recovery with regular intravenous immunoglobulin (IVIg) infusion in relatively low dose (55 g the first day followed by 50 g/day the second and third day, subsequently he was given 50 g/day for 3 days every 6 weeks). His symptoms relapsed when the IVIgs were discontinued for 28 weeks but remitted again following recommencement of IVIg infusions (50 g/day for 3 days every 7 weeks). Our case suggests IVIgs are an effective and well tolerated alternative to steroids and immunosuppressants.
format Online
Article
Text
id pubmed-7247403
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-72474032020-06-03 Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin Güngör, Cansu Wieshmann, Udo Carl BMJ Case Rep Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) Statin-induced autoimmune necrotising myopathy causes a severe progressive muscle weakness even when the statins are discontinued. First-line treatment is usually with high dose steroids followed by immunosuppressants, but this is often ineffective and there is a high risk of side effects. We describe a diabetic patient who had a very severe statin-induced autoimmune myopathy. He made a full recovery with regular intravenous immunoglobulin (IVIg) infusion in relatively low dose (55 g the first day followed by 50 g/day the second and third day, subsequently he was given 50 g/day for 3 days every 6 weeks). His symptoms relapsed when the IVIgs were discontinued for 28 weeks but remitted again following recommencement of IVIg infusions (50 g/day for 3 days every 7 weeks). Our case suggests IVIgs are an effective and well tolerated alternative to steroids and immunosuppressants. BMJ Publishing Group 2020-05-21 /pmc/articles/PMC7247403/ /pubmed/32444443 http://dx.doi.org/10.1136/bcr-2020-234805 Text en © BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
Güngör, Cansu
Wieshmann, Udo Carl
Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin
title Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin
title_full Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin
title_fullStr Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin
title_full_unstemmed Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin
title_short Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin
title_sort severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin
topic Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247403/
https://www.ncbi.nlm.nih.gov/pubmed/32444443
http://dx.doi.org/10.1136/bcr-2020-234805
work_keys_str_mv AT gungorcansu severestatininducedautoimmunemyopathysuccessfullytreatedwithintravenousimmunoglobulin
AT wieshmannudocarl severestatininducedautoimmunemyopathysuccessfullytreatedwithintravenousimmunoglobulin