Cargando…
Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin
Statin-induced autoimmune necrotising myopathy causes a severe progressive muscle weakness even when the statins are discontinued. First-line treatment is usually with high dose steroids followed by immunosuppressants, but this is often ineffective and there is a high risk of side effects. We descri...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247403/ https://www.ncbi.nlm.nih.gov/pubmed/32444443 http://dx.doi.org/10.1136/bcr-2020-234805 |
_version_ | 1783538148434771968 |
---|---|
author | Güngör, Cansu Wieshmann, Udo Carl |
author_facet | Güngör, Cansu Wieshmann, Udo Carl |
author_sort | Güngör, Cansu |
collection | PubMed |
description | Statin-induced autoimmune necrotising myopathy causes a severe progressive muscle weakness even when the statins are discontinued. First-line treatment is usually with high dose steroids followed by immunosuppressants, but this is often ineffective and there is a high risk of side effects. We describe a diabetic patient who had a very severe statin-induced autoimmune myopathy. He made a full recovery with regular intravenous immunoglobulin (IVIg) infusion in relatively low dose (55 g the first day followed by 50 g/day the second and third day, subsequently he was given 50 g/day for 3 days every 6 weeks). His symptoms relapsed when the IVIgs were discontinued for 28 weeks but remitted again following recommencement of IVIg infusions (50 g/day for 3 days every 7 weeks). Our case suggests IVIgs are an effective and well tolerated alternative to steroids and immunosuppressants. |
format | Online Article Text |
id | pubmed-7247403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-72474032020-06-03 Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin Güngör, Cansu Wieshmann, Udo Carl BMJ Case Rep Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) Statin-induced autoimmune necrotising myopathy causes a severe progressive muscle weakness even when the statins are discontinued. First-line treatment is usually with high dose steroids followed by immunosuppressants, but this is often ineffective and there is a high risk of side effects. We describe a diabetic patient who had a very severe statin-induced autoimmune myopathy. He made a full recovery with regular intravenous immunoglobulin (IVIg) infusion in relatively low dose (55 g the first day followed by 50 g/day the second and third day, subsequently he was given 50 g/day for 3 days every 6 weeks). His symptoms relapsed when the IVIgs were discontinued for 28 weeks but remitted again following recommencement of IVIg infusions (50 g/day for 3 days every 7 weeks). Our case suggests IVIgs are an effective and well tolerated alternative to steroids and immunosuppressants. BMJ Publishing Group 2020-05-21 /pmc/articles/PMC7247403/ /pubmed/32444443 http://dx.doi.org/10.1136/bcr-2020-234805 Text en © BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) Güngör, Cansu Wieshmann, Udo Carl Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin |
title | Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin |
title_full | Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin |
title_fullStr | Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin |
title_full_unstemmed | Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin |
title_short | Severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin |
title_sort | severe statin-induced autoimmune myopathy successfully treated with intravenous immunoglobulin |
topic | Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247403/ https://www.ncbi.nlm.nih.gov/pubmed/32444443 http://dx.doi.org/10.1136/bcr-2020-234805 |
work_keys_str_mv | AT gungorcansu severestatininducedautoimmunemyopathysuccessfullytreatedwithintravenousimmunoglobulin AT wieshmannudocarl severestatininducedautoimmunemyopathysuccessfullytreatedwithintravenousimmunoglobulin |