Hedgehog Signal Inhibitor GANT61 Inhibits the Malignant Behavior of Undifferentiated Hepatocellular Carcinoma Cells by Targeting Non-Canonical GLI Signaling

The Hedgehog (HH)–GLI pathway plays an important role in cell dedifferentiation and is therefore pivotally involved in the malignant transformation of cancer cells. GANT61, a selective inhibitor of GLI1 and GLI2, was reported as a promising treatment for cancer in various tissues; however, the biolo...

Descripción completa

Detalles Bibliográficos
Autores principales: Harada, Kensuke, Ohashi, Ryuya, Naito, Kyoko, Kanki, Keita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247445/
https://www.ncbi.nlm.nih.gov/pubmed/32354204
http://dx.doi.org/10.3390/ijms21093126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247445/
https://www.ncbi.nlm.nih.gov/pubmed/32354204
http://dx.doi.org/10.3390/ijms21093126

Ejemplares similares