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Hedgehog Signal Inhibitor GANT61 Inhibits the Malignant Behavior of Undifferentiated Hepatocellular Carcinoma Cells by Targeting Non-Canonical GLI Signaling

The Hedgehog (HH)–GLI pathway plays an important role in cell dedifferentiation and is therefore pivotally involved in the malignant transformation of cancer cells. GANT61, a selective inhibitor of GLI1 and GLI2, was reported as a promising treatment for cancer in various tissues; however, the biolo...

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Detalles Bibliográficos
Autores principales:	Harada, Kensuke, Ohashi, Ryuya, Naito, Kyoko, Kanki, Keita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247445/ https://www.ncbi.nlm.nih.gov/pubmed/32354204 http://dx.doi.org/10.3390/ijms21093126

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