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Pulmonary embolism: A complication of COVID 19 infection

The Coronavirus Disease 2019 (COVID 19) has been reported in almost every country in the world. Although a large proportion of infected individuals develop only mild symptoms or are asymptomatic, the spectrum of the disease among others has been widely variable in severity. Additionally, many infect...

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Autores principales: Akel, Tamer, Qaqa, Firas, Abuarqoub, Ahmad, Shamoon, Fayez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247481/
https://www.ncbi.nlm.nih.gov/pubmed/32526545
http://dx.doi.org/10.1016/j.thromres.2020.05.033
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author Akel, Tamer
Qaqa, Firas
Abuarqoub, Ahmad
Shamoon, Fayez
author_facet Akel, Tamer
Qaqa, Firas
Abuarqoub, Ahmad
Shamoon, Fayez
author_sort Akel, Tamer
collection PubMed
description The Coronavirus Disease 2019 (COVID 19) has been reported in almost every country in the world. Although a large proportion of infected individuals develop only mild symptoms or are asymptomatic, the spectrum of the disease among others has been widely variable in severity. Additionally, many infected individuals were found to have coagulation markers abnormalities. This is especially true among those progressing to severe pneumonia and multi-organ failure. While the incidence of venous thromboembolic (VTE) disease has been recently noted to be elevated among critically ill patients, the incidence among ambulatory and non-critically ill patients is not yet clearly defined. Herein, we present six patients who didn't have any hypercoagulable risk factors yet presented with pulmonary embolism in association with COVID 19 infection. Furthermore, we discuss the possible underlying mechanisms of hypercoagulability and highlight the possibility of underdiagnosing pulmonary embolism in the setting of overlapping symptoms, decreased utilization of imaging secondary to associated risks, and increased turnover times. In addition, we emphasize the role of extended thromboprophylaxis in discharged patients.
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spelling pubmed-72474812020-05-26 Pulmonary embolism: A complication of COVID 19 infection Akel, Tamer Qaqa, Firas Abuarqoub, Ahmad Shamoon, Fayez Thromb Res Article The Coronavirus Disease 2019 (COVID 19) has been reported in almost every country in the world. Although a large proportion of infected individuals develop only mild symptoms or are asymptomatic, the spectrum of the disease among others has been widely variable in severity. Additionally, many infected individuals were found to have coagulation markers abnormalities. This is especially true among those progressing to severe pneumonia and multi-organ failure. While the incidence of venous thromboembolic (VTE) disease has been recently noted to be elevated among critically ill patients, the incidence among ambulatory and non-critically ill patients is not yet clearly defined. Herein, we present six patients who didn't have any hypercoagulable risk factors yet presented with pulmonary embolism in association with COVID 19 infection. Furthermore, we discuss the possible underlying mechanisms of hypercoagulability and highlight the possibility of underdiagnosing pulmonary embolism in the setting of overlapping symptoms, decreased utilization of imaging secondary to associated risks, and increased turnover times. In addition, we emphasize the role of extended thromboprophylaxis in discharged patients. Elsevier Ltd. 2020-09 2020-05-25 /pmc/articles/PMC7247481/ /pubmed/32526545 http://dx.doi.org/10.1016/j.thromres.2020.05.033 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Akel, Tamer
Qaqa, Firas
Abuarqoub, Ahmad
Shamoon, Fayez
Pulmonary embolism: A complication of COVID 19 infection
title Pulmonary embolism: A complication of COVID 19 infection
title_full Pulmonary embolism: A complication of COVID 19 infection
title_fullStr Pulmonary embolism: A complication of COVID 19 infection
title_full_unstemmed Pulmonary embolism: A complication of COVID 19 infection
title_short Pulmonary embolism: A complication of COVID 19 infection
title_sort pulmonary embolism: a complication of covid 19 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247481/
https://www.ncbi.nlm.nih.gov/pubmed/32526545
http://dx.doi.org/10.1016/j.thromres.2020.05.033
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