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A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets

Recent studies have shown that the innate and adaptive immune system, together with low-grade inflammation, may play an important role in essential hypertension. In this work, to verify the importance of selected factors for the development of essential hypertension, we created a Petri net-based mod...

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Autores principales: Formanowicz, Dorota, Rybarczyk, Agnieszka, Radom, Marcin, Formanowicz, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247551/
https://www.ncbi.nlm.nih.gov/pubmed/32397357
http://dx.doi.org/10.3390/ijms21093348
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author Formanowicz, Dorota
Rybarczyk, Agnieszka
Radom, Marcin
Formanowicz, Piotr
author_facet Formanowicz, Dorota
Rybarczyk, Agnieszka
Radom, Marcin
Formanowicz, Piotr
author_sort Formanowicz, Dorota
collection PubMed
description Recent studies have shown that the innate and adaptive immune system, together with low-grade inflammation, may play an important role in essential hypertension. In this work, to verify the importance of selected factors for the development of essential hypertension, we created a Petri net-based model and analyzed it. The analysis was based mainly on t-invariants, knockouts of selected fragments of the net and its simulations. The blockade of the renin-angiotensin (RAA) system revealed that the most significant effect on the emergence of essential hypertension has RAA activation. This blockade affects: (1) the formation of angiotensin II, (2) inflammatory process (by influencing C-reactive protein (CRP)), (3) the initiation of blood coagulation, (4) bradykinin generation via the kallikrein-kinin system, (5) activation of lymphocytes in hypertension, (6) the participation of TNF alpha in the activation of the acute phase response, and (7) activation of NADPH oxidase—a key enzyme of oxidative stress. On the other hand, we found that the blockade of the activation of the RAA system may not eliminate hypertension that can occur due to disturbances associated with the osmotically independent binding of Na in the interstitium. Moreover, we revealed that inflammation alone is not enough to trigger primary hypertension, but it can coexist with it. We believe that our research may contribute to a better understanding of the pathology of hypertension. It can help identify potential subprocesses, which blocking will allow better control of essential hypertension.
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spelling pubmed-72475512020-06-10 A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets Formanowicz, Dorota Rybarczyk, Agnieszka Radom, Marcin Formanowicz, Piotr Int J Mol Sci Article Recent studies have shown that the innate and adaptive immune system, together with low-grade inflammation, may play an important role in essential hypertension. In this work, to verify the importance of selected factors for the development of essential hypertension, we created a Petri net-based model and analyzed it. The analysis was based mainly on t-invariants, knockouts of selected fragments of the net and its simulations. The blockade of the renin-angiotensin (RAA) system revealed that the most significant effect on the emergence of essential hypertension has RAA activation. This blockade affects: (1) the formation of angiotensin II, (2) inflammatory process (by influencing C-reactive protein (CRP)), (3) the initiation of blood coagulation, (4) bradykinin generation via the kallikrein-kinin system, (5) activation of lymphocytes in hypertension, (6) the participation of TNF alpha in the activation of the acute phase response, and (7) activation of NADPH oxidase—a key enzyme of oxidative stress. On the other hand, we found that the blockade of the activation of the RAA system may not eliminate hypertension that can occur due to disturbances associated with the osmotically independent binding of Na in the interstitium. Moreover, we revealed that inflammation alone is not enough to trigger primary hypertension, but it can coexist with it. We believe that our research may contribute to a better understanding of the pathology of hypertension. It can help identify potential subprocesses, which blocking will allow better control of essential hypertension. MDPI 2020-05-09 /pmc/articles/PMC7247551/ /pubmed/32397357 http://dx.doi.org/10.3390/ijms21093348 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Formanowicz, Dorota
Rybarczyk, Agnieszka
Radom, Marcin
Formanowicz, Piotr
A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets
title A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets
title_full A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets
title_fullStr A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets
title_full_unstemmed A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets
title_short A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets
title_sort role of inflammation and immunity in essential hypertension—modeled and analyzed using petri nets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247551/
https://www.ncbi.nlm.nih.gov/pubmed/32397357
http://dx.doi.org/10.3390/ijms21093348
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