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Influence of Innate Immunity on Cancer Cell Stemness
Even if cancer stem cells (CSCs) represent only a small proportion of the tumor mass, they significantly account for tumor maintenance, resistance to therapies, relapse and metastatic spread, due to their increased capacity of self-renewal, multipotency, tumorigenicity and quiescence. Emerging evide...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247585/ https://www.ncbi.nlm.nih.gov/pubmed/32397392 http://dx.doi.org/10.3390/ijms21093352 |
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author | Pastò, Anna Consonni, Francesca Maria Sica, Antonio |
author_facet | Pastò, Anna Consonni, Francesca Maria Sica, Antonio |
author_sort | Pastò, Anna |
collection | PubMed |
description | Even if cancer stem cells (CSCs) represent only a small proportion of the tumor mass, they significantly account for tumor maintenance, resistance to therapies, relapse and metastatic spread, due to their increased capacity of self-renewal, multipotency, tumorigenicity and quiescence. Emerging evidence suggests that the immune contexture within the tumor microenvironment (TME) determines both the response to therapy and the clinical outcome. In this context, CSCs acquire immune evasion skills by editing immune cell functions and sculpting the immunosuppressive landscape of TME. Reciprocally, infiltrating immune cells influence CSCs self-renewal, tumorigenicity and metastasis. In this review, we summarize the immunomodulatory properties of CSCs, as well as the impact of innate immune cells on cancer cells stemness in the different phases of cancer immunoediting process and neoplastic progression. |
format | Online Article Text |
id | pubmed-7247585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72475852020-06-10 Influence of Innate Immunity on Cancer Cell Stemness Pastò, Anna Consonni, Francesca Maria Sica, Antonio Int J Mol Sci Review Even if cancer stem cells (CSCs) represent only a small proportion of the tumor mass, they significantly account for tumor maintenance, resistance to therapies, relapse and metastatic spread, due to their increased capacity of self-renewal, multipotency, tumorigenicity and quiescence. Emerging evidence suggests that the immune contexture within the tumor microenvironment (TME) determines both the response to therapy and the clinical outcome. In this context, CSCs acquire immune evasion skills by editing immune cell functions and sculpting the immunosuppressive landscape of TME. Reciprocally, infiltrating immune cells influence CSCs self-renewal, tumorigenicity and metastasis. In this review, we summarize the immunomodulatory properties of CSCs, as well as the impact of innate immune cells on cancer cells stemness in the different phases of cancer immunoediting process and neoplastic progression. MDPI 2020-05-09 /pmc/articles/PMC7247585/ /pubmed/32397392 http://dx.doi.org/10.3390/ijms21093352 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pastò, Anna Consonni, Francesca Maria Sica, Antonio Influence of Innate Immunity on Cancer Cell Stemness |
title | Influence of Innate Immunity on Cancer Cell Stemness |
title_full | Influence of Innate Immunity on Cancer Cell Stemness |
title_fullStr | Influence of Innate Immunity on Cancer Cell Stemness |
title_full_unstemmed | Influence of Innate Immunity on Cancer Cell Stemness |
title_short | Influence of Innate Immunity on Cancer Cell Stemness |
title_sort | influence of innate immunity on cancer cell stemness |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247585/ https://www.ncbi.nlm.nih.gov/pubmed/32397392 http://dx.doi.org/10.3390/ijms21093352 |
work_keys_str_mv | AT pastoanna influenceofinnateimmunityoncancercellstemness AT consonnifrancescamaria influenceofinnateimmunityoncancercellstemness AT sicaantonio influenceofinnateimmunityoncancercellstemness |