Cargando…

Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation

Although various advancements in radical surgery and neoadjuvant chemotherapy have been developed in treating osteosarcoma (OS), their clinical prognosis remains poor. A synthetic chemical compound, 3-hydroxylflavone, that is reported to regulate ROS production is known to inhibit human bone osteosa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Chien-Yao, Lay, Ing-Shiow, Shibu, Marthandam Asokan, Tseng, Yan-Shen, Kuo, Wei-Wen, Yang, Jaw-Ji, Wang, Tso-Fu, Mahalakshmi, B., Yeh, Yu-Lan, Huang, Chih-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247666/ https://www.ncbi.nlm.nih.gov/pubmed/32397561 http://dx.doi.org/10.3390/ijms21093366

Ejemplares similares

Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis
por: Lay, Ing-Shiow, et al.
Publicado: (2020)

RhoGDIβ-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK
por: Huang, Chih-Yang, et al.
Publicado: (2009)

ZAK negatively regulates RhoGDIβ-induced Rac1-mediated hypertrophic growth and cell migration
por: Huang, Chih-Yang, et al.
Publicado: (2009)

A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway
por: Asokan, Shibu Marthandam, et al.
Publicado: (2020)

A Requirement for ZAK Kinase Activity in Canonical TGF-β Signaling()
por: Nyati, Shyam, et al.
Publicado: (2016)

Measuring Zak phase in room-temperature atoms
por: Mao, Ruosong, et al.
Publicado: (2022)

Direct extraction of topological Zak phase with the synthetic dimension
por: Li, Guangzhen, et al.
Publicado: (2023)

Chemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the GNL3L and NF-κB Pathway
por: Kannathasan, Thetchinamoorthy, et al.
Publicado: (2020)

Antidiabetic Effects of a Short Peptide of Potato Protein Hydrolysate in STZ-Induced Diabetic Mice
por: Marthandam Asokan, Shibu, et al.
Publicado: (2019)

Anti-Fatigue and Exercise Performance Improvement Effect of Glossogyne tenuifolia Extract in Mice
por: Chen, Yi-Ju, et al.
Publicado: (2022)

Topics in the geometry of projective space: recent work of FL Zak
por: Lazarsfeld, R, et al.
Publicado: (1984)

Computational and Functional Analysis of Structural Features in the ZAKα Kinase
por: Johansen, Valdemar Brimnes Ingemann, et al.
Publicado: (2023)

Hepato-protective effects of Glossogyne tenuifolia in Streptozotocin-nicotinamide-induced diabetic rats on high fat diet
por: Asokan, Shibu Marthandam, et al.
Publicado: (2019)

ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle
por: Nordgaard, Cathrine, et al.
Publicado: (2022)

ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome
por: Rodríguez‐Ruiz, Lola, et al.
Publicado: (2023)

Long-range ballistic transport of Brown-Zak fermions in graphene superlattices
por: Barrier, Julien, et al.
Publicado: (2020)

Orthogonal Time Frequency Space Modulation Based on the Discrete Zak Transform
por: Lampel, Franz, et al.
Publicado: (2022)

Synthesis and Antibacterial Activities of Novel 4-Hydroxy-7-hydroxy- and 3-Carboxycoumarin Derivatives
por: Lin, Pen-Yuan, et al.
Publicado: (2012)

Protein hydrolysate from potato confers hepatic-protection in hamsters against high fat diet induced apoptosis and fibrosis by suppressing Caspase-3 and MMP2/9 and by enhancing Akt-survival pathway
por: Asokan, Shibu Marthandam, et al.
Publicado: (2019)

Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin
por: Wong, John, et al.
Publicado: (2013)

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer
por: Liu, Jinfeng, et al.
Publicado: (2014)

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response
por: Jandhyala, Dakshina M., et al.
Publicado: (2016)

Mixed lineage kinase ZAK promotes epithelial–mesenchymal transition in cancer progression
por: Li, Linna, et al.
Publicado: (2018)

Acacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation
por: Wang, Shubin, et al.
Publicado: (2020)

Detection of Zak phases and topological invariants in a chiral quantum walk of twisted photons
por: Cardano, Filippo, et al.
Publicado: (2017)

ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition
por: Maruyama, Takeshi, et al.
Publicado: (2020)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
por: Yuan, Yong-Liang, et al.
Publicado: (2019)

JNK Inactivation Induces Polyploidy and Drug-Resistance in Coronarin D-Treated Osteosarcoma Cells
por: Hsu, Chang-Te, et al.
Publicado: (2018)

Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer
por: Tang, Jing, et al.
Publicado: (2019)

Initiation of a ZAKα-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L
por: Xi, Jiajia, et al.
Publicado: (2023)

E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages
por: Ali, Ayaz, et al.
Publicado: (2021)

Daidzein Synergizes with Gefitinib to Induce ROS/JNK/c-Jun Activation and Inhibit EGFR-STAT/AKT/ERK Pathways to enhance Lung Adenocarcinoma cells chemosensitivity
por: Mhone, Thomas Gabriel, et al.
Publicado: (2022)

CLEFMA Activates the Extrinsic and Intrinsic Apoptotic Processes through JNK1/2 and p38 Pathways in Human Osteosarcoma Cells
por: Yang, Jia-Sin, et al.
Publicado: (2019)

Are You Responsible for Your Hormones?: Review: The Moral Molecule: The Source of Love and Prosperity by Paul J. Zak, Ph.D.
por: Flanagan-Cato, Loretta M.
Publicado: (2012)

Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice
por: Spielmann, Malte, et al.
Publicado: (2016)

HO-3867 Induces Apoptosis via the JNK Signaling Pathway in Human Osteosarcoma Cells
por: Lu, Peace Wun-Ang, et al.
Publicado: (2022)

Emergence of spin-orbit coupled ferromagnetic surface state derived from Zak phase in a nonmagnetic insulator FeSi
por: Ohtsuka, Yusuke, et al.
Publicado: (2021)

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression
por: Cheng, Hsin-Lin, et al.
Publicado: (2016)

GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling
por: Lu, Peace Wun-Ang, et al.
Publicado: (2021)

Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson’s Disease Associated α-Synuclein Levels
por: Huang, Chih-Yang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_beba86niokm824lpt6i7c5im9d