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Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap

PURPOSE: The aim of this study was to evaluate the clinical outcomes of management of recurrent pterygium with severe symblepharon using mitomycin C, double amniotic membrane transplantation, cryopreserved limbal allograft, and a conjunctival flap. PATIENTS AND METHODS: This retrospective case serie...

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Autores principales: Monden, Yu, Nagashima, Chikako, Yokote, Noriko, Hotokezaka, Fumi, Maeda, Satoshi, Sasaki, Kensuke, Yamakawa, Ryoji, Yoshida, Shigeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247734/
https://www.ncbi.nlm.nih.gov/pubmed/32547257
http://dx.doi.org/10.2147/IMCRJ.S245256
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author Monden, Yu
Nagashima, Chikako
Yokote, Noriko
Hotokezaka, Fumi
Maeda, Satoshi
Sasaki, Kensuke
Yamakawa, Ryoji
Yoshida, Shigeo
author_facet Monden, Yu
Nagashima, Chikako
Yokote, Noriko
Hotokezaka, Fumi
Maeda, Satoshi
Sasaki, Kensuke
Yamakawa, Ryoji
Yoshida, Shigeo
author_sort Monden, Yu
collection PubMed
description PURPOSE: The aim of this study was to evaluate the clinical outcomes of management of recurrent pterygium with severe symblepharon using mitomycin C, double amniotic membrane transplantation, cryopreserved limbal allograft, and a conjunctival flap. PATIENTS AND METHODS: This retrospective case series included 10 eyes of 10 patients with recurrent pterygium with severe symblepharon. Eight patients have diplopia in primary gaze. All patients underwent pterygium excision, application of mitomycin C (MMC), double amniotic membrane transplantation (AMT), cryopreserved limbal allograft (CLA) transplantation, and placement of a conjunctival flap. Outcome measures were visual acuity, astigmatism, and recurrence. Recurrence was defined as the presence of fibrovascular proliferative tissue crossing the limbus. RESULTS: The patients’ mean age was 73.8 years. The mean follow-up period was 3.0 years. The mean preoperative and postoperative best-corrected visual acuities (logMAR conversion) were 0.43 and 0.30, respectively. The mean preoperative and postoperative astigmatism were –3.89 diopters and –1.54 diopters, respectively, and there was a significant difference. No recurrence occurred in any of the eyes. Symblepharon was released in all eyes. Diplopia in primary gaze was resolved in all eyes. CONCLUSION: Management of recurrent pterygium with severe symblepharon using MMC, double AMT, CLA, and a conjunctival flap was an effective treatment.
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spelling pubmed-72477342020-06-15 Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap Monden, Yu Nagashima, Chikako Yokote, Noriko Hotokezaka, Fumi Maeda, Satoshi Sasaki, Kensuke Yamakawa, Ryoji Yoshida, Shigeo Int Med Case Rep J Case Series PURPOSE: The aim of this study was to evaluate the clinical outcomes of management of recurrent pterygium with severe symblepharon using mitomycin C, double amniotic membrane transplantation, cryopreserved limbal allograft, and a conjunctival flap. PATIENTS AND METHODS: This retrospective case series included 10 eyes of 10 patients with recurrent pterygium with severe symblepharon. Eight patients have diplopia in primary gaze. All patients underwent pterygium excision, application of mitomycin C (MMC), double amniotic membrane transplantation (AMT), cryopreserved limbal allograft (CLA) transplantation, and placement of a conjunctival flap. Outcome measures were visual acuity, astigmatism, and recurrence. Recurrence was defined as the presence of fibrovascular proliferative tissue crossing the limbus. RESULTS: The patients’ mean age was 73.8 years. The mean follow-up period was 3.0 years. The mean preoperative and postoperative best-corrected visual acuities (logMAR conversion) were 0.43 and 0.30, respectively. The mean preoperative and postoperative astigmatism were –3.89 diopters and –1.54 diopters, respectively, and there was a significant difference. No recurrence occurred in any of the eyes. Symblepharon was released in all eyes. Diplopia in primary gaze was resolved in all eyes. CONCLUSION: Management of recurrent pterygium with severe symblepharon using MMC, double AMT, CLA, and a conjunctival flap was an effective treatment. Dove 2020-05-21 /pmc/articles/PMC7247734/ /pubmed/32547257 http://dx.doi.org/10.2147/IMCRJ.S245256 Text en © 2020 Monden et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Series
Monden, Yu
Nagashima, Chikako
Yokote, Noriko
Hotokezaka, Fumi
Maeda, Satoshi
Sasaki, Kensuke
Yamakawa, Ryoji
Yoshida, Shigeo
Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap
title Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap
title_full Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap
title_fullStr Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap
title_full_unstemmed Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap
title_short Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap
title_sort management of recurrent pterygium with severe symblepharon using mitomycin c, double amniotic membrane transplantation, cryopreserved limbal allograft, and a conjunctival flap
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247734/
https://www.ncbi.nlm.nih.gov/pubmed/32547257
http://dx.doi.org/10.2147/IMCRJ.S245256
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