Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19

The COVID-19 pandemic has highlighted an important role for drug repurposing. Quaternary ammonium compounds such as ammonium chloride, cetylpyridinium and miramistin represent widely accessible antiseptic molecules with well-known broad-spectrum antiviral activities and represent a repurposing oppor...

Descripción completa

Detalles Bibliográficos
Autores principales: Baker, Nancy, Williams, Antony J., Tropsha, Alexander, Ekins, Sean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247743/
https://www.ncbi.nlm.nih.gov/pubmed/32451736
http://dx.doi.org/10.1007/s11095-020-02842-8
_version_ 1783538224389423104
author Baker, Nancy
Williams, Antony J.
Tropsha, Alexander
Ekins, Sean
author_facet Baker, Nancy
Williams, Antony J.
Tropsha, Alexander
Ekins, Sean
author_sort Baker, Nancy
collection PubMed
description The COVID-19 pandemic has highlighted an important role for drug repurposing. Quaternary ammonium compounds such as ammonium chloride, cetylpyridinium and miramistin represent widely accessible antiseptic molecules with well-known broad-spectrum antiviral activities and represent a repurposing opportunity as therapeutics against SARS-CoV-2. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11095-020-02842-8) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-7247743
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-72477432020-05-26 Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19 Baker, Nancy Williams, Antony J. Tropsha, Alexander Ekins, Sean Pharm Res Perspective The COVID-19 pandemic has highlighted an important role for drug repurposing. Quaternary ammonium compounds such as ammonium chloride, cetylpyridinium and miramistin represent widely accessible antiseptic molecules with well-known broad-spectrum antiviral activities and represent a repurposing opportunity as therapeutics against SARS-CoV-2. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11095-020-02842-8) contains supplementary material, which is available to authorized users. Springer US 2020-05-25 2020 /pmc/articles/PMC7247743/ /pubmed/32451736 http://dx.doi.org/10.1007/s11095-020-02842-8 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Perspective
Baker, Nancy
Williams, Antony J.
Tropsha, Alexander
Ekins, Sean
Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19
title Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19
title_full Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19
title_fullStr Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19
title_full_unstemmed Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19
title_short Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19
title_sort repurposing quaternary ammonium compounds as potential treatments for covid-19
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247743/
https://www.ncbi.nlm.nih.gov/pubmed/32451736
http://dx.doi.org/10.1007/s11095-020-02842-8
work_keys_str_mv AT bakernancy repurposingquaternaryammoniumcompoundsaspotentialtreatmentsforcovid19
AT williamsantonyj repurposingquaternaryammoniumcompoundsaspotentialtreatmentsforcovid19
AT tropshaalexander repurposingquaternaryammoniumcompoundsaspotentialtreatmentsforcovid19
AT ekinssean repurposingquaternaryammoniumcompoundsaspotentialtreatmentsforcovid19

Ejemplares similares