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Maternal choline and respiratory coronavirus effects on fetal brain development

Prenatal COVID-19 infection is anticipated by the U.S. Centers for Disease Control to affect fetal development similarly to other common respiratory coronaviruses through effects of the maternal inflammatory response on the fetus and placenta. Plasma choline levels were measured at 16 weeks gestatio...

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Detalles Bibliográficos
Autores principales: Freedman, Robert, Hunter, Sharon K., Law, Amanda J., D'Alessandro, Angelo, Noonan, Kathleen, Wyrwa, Anna, Camille Hoffman, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247782/
https://www.ncbi.nlm.nih.gov/pubmed/32474140
http://dx.doi.org/10.1016/j.jpsychires.2020.05.019
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author Freedman, Robert
Hunter, Sharon K.
Law, Amanda J.
D'Alessandro, Angelo
Noonan, Kathleen
Wyrwa, Anna
Camille Hoffman, M.
author_facet Freedman, Robert
Hunter, Sharon K.
Law, Amanda J.
D'Alessandro, Angelo
Noonan, Kathleen
Wyrwa, Anna
Camille Hoffman, M.
author_sort Freedman, Robert
collection PubMed
description Prenatal COVID-19 infection is anticipated by the U.S. Centers for Disease Control to affect fetal development similarly to other common respiratory coronaviruses through effects of the maternal inflammatory response on the fetus and placenta. Plasma choline levels were measured at 16 weeks gestation in 43 mothers who had contracted common respiratory viruses during the first 6–16 weeks of pregnancy and 53 mothers who had not. When their infants reached 3 months of age, mothers completed the Infant Behavior Questionnaire-Revised (IBQ-R), which assesses their infants’ level of activity (Surgency), their fearfulness and sadness (Negativity), and their ability to maintain attention and bond to their parents and caretakers (Regulation). Infants of mothers who had contracted a moderately severe respiratory virus infection and had higher gestational choline serum levels (≥7.5 mM consistent with U.S. Food and Drug Administration dietary recommendations) had significantly increased development of their ability to maintain attention and to bond with their parents (Regulation), compared to infants whose mothers had contracted an infection but had lower choline levels (<7.5 mM). For infants of mothers with choline levels ≥7.5 μM, there was no effect of viral infection on infant IBQ-R Regulation, compared to infants of mothers who were not infected. Higher choline levels obtained through diet or supplements may protect fetal development and support infant early behavioral development even if the mother contracts a viral infection in early gestation when the brain is first being formed.
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spelling pubmed-72477822020-05-26 Maternal choline and respiratory coronavirus effects on fetal brain development Freedman, Robert Hunter, Sharon K. Law, Amanda J. D'Alessandro, Angelo Noonan, Kathleen Wyrwa, Anna Camille Hoffman, M. J Psychiatr Res Article Prenatal COVID-19 infection is anticipated by the U.S. Centers for Disease Control to affect fetal development similarly to other common respiratory coronaviruses through effects of the maternal inflammatory response on the fetus and placenta. Plasma choline levels were measured at 16 weeks gestation in 43 mothers who had contracted common respiratory viruses during the first 6–16 weeks of pregnancy and 53 mothers who had not. When their infants reached 3 months of age, mothers completed the Infant Behavior Questionnaire-Revised (IBQ-R), which assesses their infants’ level of activity (Surgency), their fearfulness and sadness (Negativity), and their ability to maintain attention and bond to their parents and caretakers (Regulation). Infants of mothers who had contracted a moderately severe respiratory virus infection and had higher gestational choline serum levels (≥7.5 mM consistent with U.S. Food and Drug Administration dietary recommendations) had significantly increased development of their ability to maintain attention and to bond with their parents (Regulation), compared to infants whose mothers had contracted an infection but had lower choline levels (<7.5 mM). For infants of mothers with choline levels ≥7.5 μM, there was no effect of viral infection on infant IBQ-R Regulation, compared to infants of mothers who were not infected. Higher choline levels obtained through diet or supplements may protect fetal development and support infant early behavioral development even if the mother contracts a viral infection in early gestation when the brain is first being formed. Elsevier Ltd. 2020-09 2020-05-25 /pmc/articles/PMC7247782/ /pubmed/32474140 http://dx.doi.org/10.1016/j.jpsychires.2020.05.019 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Freedman, Robert
Hunter, Sharon K.
Law, Amanda J.
D'Alessandro, Angelo
Noonan, Kathleen
Wyrwa, Anna
Camille Hoffman, M.
Maternal choline and respiratory coronavirus effects on fetal brain development
title Maternal choline and respiratory coronavirus effects on fetal brain development
title_full Maternal choline and respiratory coronavirus effects on fetal brain development
title_fullStr Maternal choline and respiratory coronavirus effects on fetal brain development
title_full_unstemmed Maternal choline and respiratory coronavirus effects on fetal brain development
title_short Maternal choline and respiratory coronavirus effects on fetal brain development
title_sort maternal choline and respiratory coronavirus effects on fetal brain development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247782/
https://www.ncbi.nlm.nih.gov/pubmed/32474140
http://dx.doi.org/10.1016/j.jpsychires.2020.05.019
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