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Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma

Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of ski...

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Autores principales: Li, Xin-Ying, Tan, Liu-Chang, Dong, Li-Wen, Zhang, Wan-Qi, Shen, Xiao-Xiao, Lu, Xiao, Zheng, Hong, Lu, Yuan-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247862/
https://www.ncbi.nlm.nih.gov/pubmed/32528867
http://dx.doi.org/10.3389/fonc.2020.00597
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author Li, Xin-Ying
Tan, Liu-Chang
Dong, Li-Wen
Zhang, Wan-Qi
Shen, Xiao-Xiao
Lu, Xiao
Zheng, Hong
Lu, Yuan-Gang
author_facet Li, Xin-Ying
Tan, Liu-Chang
Dong, Li-Wen
Zhang, Wan-Qi
Shen, Xiao-Xiao
Lu, Xiao
Zheng, Hong
Lu, Yuan-Gang
author_sort Li, Xin-Ying
collection PubMed
description Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of skin diseases. Photodynamic therapy is a relatively new treatment method for various types of malignant tumors in humans and, compared to conventional treatment methods, has fewer side effects, and is more accurate and non-invasive. Although several in vivo and in vitro studies have shown encouraging results regarding the potential benefits of photodynamic therapy as an adjuvant treatment for melanoma, its clinical application remains limited owing to its relative inefficiency. This review article discusses the use of photodynamic therapy in melanoma treatment as well as the latest progress made in deciphering the mechanism of tolerance. Lastly, potential targets are identified that may improve photodynamic therapy against melanoma cells.
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spelling pubmed-72478622020-06-10 Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma Li, Xin-Ying Tan, Liu-Chang Dong, Li-Wen Zhang, Wan-Qi Shen, Xiao-Xiao Lu, Xiao Zheng, Hong Lu, Yuan-Gang Front Oncol Oncology Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of skin diseases. Photodynamic therapy is a relatively new treatment method for various types of malignant tumors in humans and, compared to conventional treatment methods, has fewer side effects, and is more accurate and non-invasive. Although several in vivo and in vitro studies have shown encouraging results regarding the potential benefits of photodynamic therapy as an adjuvant treatment for melanoma, its clinical application remains limited owing to its relative inefficiency. This review article discusses the use of photodynamic therapy in melanoma treatment as well as the latest progress made in deciphering the mechanism of tolerance. Lastly, potential targets are identified that may improve photodynamic therapy against melanoma cells. Frontiers Media S.A. 2020-05-12 /pmc/articles/PMC7247862/ /pubmed/32528867 http://dx.doi.org/10.3389/fonc.2020.00597 Text en Copyright © 2020 Li, Tan, Dong, Zhang, Shen, Lu, Zheng and Lu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Xin-Ying
Tan, Liu-Chang
Dong, Li-Wen
Zhang, Wan-Qi
Shen, Xiao-Xiao
Lu, Xiao
Zheng, Hong
Lu, Yuan-Gang
Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma
title Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma
title_full Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma
title_fullStr Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma
title_full_unstemmed Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma
title_short Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma
title_sort susceptibility and resistance mechanisms during photodynamic therapy of melanoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247862/
https://www.ncbi.nlm.nih.gov/pubmed/32528867
http://dx.doi.org/10.3389/fonc.2020.00597
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