Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?

The increasing number of deaths due to the COVID-19 pandemic has raised serious global concerns. Increased testing capacity and ample intensive care availability could explain lower mortality in some countries compared to others. Nevertheless, it is also plausible that the SARS-CoV-2 mutations givin...

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Autores principales: Eaaswarkhanth, Muthukrishnan, Al Madhoun, Ashraf, Al-Mulla, Fahd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247990/
https://www.ncbi.nlm.nih.gov/pubmed/32464271
http://dx.doi.org/10.1016/j.ijid.2020.05.071
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author Eaaswarkhanth, Muthukrishnan
Al Madhoun, Ashraf
Al-Mulla, Fahd
author_facet Eaaswarkhanth, Muthukrishnan
Al Madhoun, Ashraf
Al-Mulla, Fahd
author_sort Eaaswarkhanth, Muthukrishnan
collection PubMed
description The increasing number of deaths due to the COVID-19 pandemic has raised serious global concerns. Increased testing capacity and ample intensive care availability could explain lower mortality in some countries compared to others. Nevertheless, it is also plausible that the SARS-CoV-2 mutations giving rise to different phylogenetic clades are responsible for the apparent death rate disparities around the world. Current research literature linking the genetic make-up of SARS-CoV-2 with fatalities is lacking. Here, we suggest that this disparity in fatality rates may be attributed to SARS-CoV-2 evolving mutations and urge the international community to begin addressing the phylogenetic clade classification of SARS-CoV-2 in relation to clinical outcomes.
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spelling pubmed-72479902020-05-26 Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality? Eaaswarkhanth, Muthukrishnan Al Madhoun, Ashraf Al-Mulla, Fahd Int J Infect Dis Short Communication The increasing number of deaths due to the COVID-19 pandemic has raised serious global concerns. Increased testing capacity and ample intensive care availability could explain lower mortality in some countries compared to others. Nevertheless, it is also plausible that the SARS-CoV-2 mutations giving rise to different phylogenetic clades are responsible for the apparent death rate disparities around the world. Current research literature linking the genetic make-up of SARS-CoV-2 with fatalities is lacking. Here, we suggest that this disparity in fatality rates may be attributed to SARS-CoV-2 evolving mutations and urge the international community to begin addressing the phylogenetic clade classification of SARS-CoV-2 in relation to clinical outcomes. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-07 2020-05-26 /pmc/articles/PMC7247990/ /pubmed/32464271 http://dx.doi.org/10.1016/j.ijid.2020.05.071 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Eaaswarkhanth, Muthukrishnan
Al Madhoun, Ashraf
Al-Mulla, Fahd
Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?
title Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?
title_full Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?
title_fullStr Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?
title_full_unstemmed Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?
title_short Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?
title_sort could the d614g substitution in the sars-cov-2 spike (s) protein be associated with higher covid-19 mortality?
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247990/
https://www.ncbi.nlm.nih.gov/pubmed/32464271
http://dx.doi.org/10.1016/j.ijid.2020.05.071
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