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Structure and function of minor pilins of type IV pili

Type IV pili are versatile and highly flexible fibers formed on the surface of many Gram-negative and Gram-positive bacteria. Virulence and infection rate of several pathogenic bacteria, such as Neisseria meningitidis and Pseudomonas aeruginosa, are strongly dependent on the presence of pili as they...

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Autores principales: Jacobsen, Theis, Bardiaux, Benjamin, Francetic, Olivera, Izadi-Pruneyre, Nadia, Nilges, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248040/
https://www.ncbi.nlm.nih.gov/pubmed/31784891
http://dx.doi.org/10.1007/s00430-019-00642-5
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author Jacobsen, Theis
Bardiaux, Benjamin
Francetic, Olivera
Izadi-Pruneyre, Nadia
Nilges, Michael
author_facet Jacobsen, Theis
Bardiaux, Benjamin
Francetic, Olivera
Izadi-Pruneyre, Nadia
Nilges, Michael
author_sort Jacobsen, Theis
collection PubMed
description Type IV pili are versatile and highly flexible fibers formed on the surface of many Gram-negative and Gram-positive bacteria. Virulence and infection rate of several pathogenic bacteria, such as Neisseria meningitidis and Pseudomonas aeruginosa, are strongly dependent on the presence of pili as they facilitate the adhesion of the bacteria to the host cell. Disruption of the interactions between the pili and the host cells by targeting proteins involved in this interaction could, therefore, be a treatment strategy. A type IV pilus is primarily composed of multiple copies of protein subunits called major pilins. Additional proteins, called minor pilins, are present in lower abundance, but are essential for the assembly of the pilus or for its specific functions. One class of minor pilins is required to initiate the formation of pili, and may form a complex similar to that identified in the related type II secretion system. Other, species-specific minor pilins in the type IV pilus system have been shown to promote additional functions such as DNA binding, aggregation and adherence. Here, we will review the structure and the function of the minor pilins from type IV pili.
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spelling pubmed-72480402020-06-03 Structure and function of minor pilins of type IV pili Jacobsen, Theis Bardiaux, Benjamin Francetic, Olivera Izadi-Pruneyre, Nadia Nilges, Michael Med Microbiol Immunol Review Type IV pili are versatile and highly flexible fibers formed on the surface of many Gram-negative and Gram-positive bacteria. Virulence and infection rate of several pathogenic bacteria, such as Neisseria meningitidis and Pseudomonas aeruginosa, are strongly dependent on the presence of pili as they facilitate the adhesion of the bacteria to the host cell. Disruption of the interactions between the pili and the host cells by targeting proteins involved in this interaction could, therefore, be a treatment strategy. A type IV pilus is primarily composed of multiple copies of protein subunits called major pilins. Additional proteins, called minor pilins, are present in lower abundance, but are essential for the assembly of the pilus or for its specific functions. One class of minor pilins is required to initiate the formation of pili, and may form a complex similar to that identified in the related type II secretion system. Other, species-specific minor pilins in the type IV pilus system have been shown to promote additional functions such as DNA binding, aggregation and adherence. Here, we will review the structure and the function of the minor pilins from type IV pili. Springer Berlin Heidelberg 2019-11-29 2020 /pmc/articles/PMC7248040/ /pubmed/31784891 http://dx.doi.org/10.1007/s00430-019-00642-5 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Jacobsen, Theis
Bardiaux, Benjamin
Francetic, Olivera
Izadi-Pruneyre, Nadia
Nilges, Michael
Structure and function of minor pilins of type IV pili
title Structure and function of minor pilins of type IV pili
title_full Structure and function of minor pilins of type IV pili
title_fullStr Structure and function of minor pilins of type IV pili
title_full_unstemmed Structure and function of minor pilins of type IV pili
title_short Structure and function of minor pilins of type IV pili
title_sort structure and function of minor pilins of type iv pili
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248040/
https://www.ncbi.nlm.nih.gov/pubmed/31784891
http://dx.doi.org/10.1007/s00430-019-00642-5
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