Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals

The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors aft...

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Autores principales: Scaduto, Pietro, Sequeira, Adolfo, Vawter, Marquis P., Bunney, William, Limon, Agenor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248056/
https://www.ncbi.nlm.nih.gov/pubmed/32451470
http://dx.doi.org/10.1038/s41598-020-65377-3
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author Scaduto, Pietro
Sequeira, Adolfo
Vawter, Marquis P.
Bunney, William
Limon, Agenor
author_facet Scaduto, Pietro
Sequeira, Adolfo
Vawter, Marquis P.
Bunney, William
Limon, Agenor
author_sort Scaduto, Pietro
collection PubMed
description The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.
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spelling pubmed-72480562020-06-04 Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals Scaduto, Pietro Sequeira, Adolfo Vawter, Marquis P. Bunney, William Limon, Agenor Sci Rep Article The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks. Nature Publishing Group UK 2020-05-25 /pmc/articles/PMC7248056/ /pubmed/32451470 http://dx.doi.org/10.1038/s41598-020-65377-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Scaduto, Pietro
Sequeira, Adolfo
Vawter, Marquis P.
Bunney, William
Limon, Agenor
Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
title Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
title_full Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
title_fullStr Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
title_full_unstemmed Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
title_short Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
title_sort preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248056/
https://www.ncbi.nlm.nih.gov/pubmed/32451470
http://dx.doi.org/10.1038/s41598-020-65377-3
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