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PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy
Pentraxin 3 (PTX3) is a main component of the innate immune system by inducing complement pathway activation, acting as an inflammatory mediator, coordinating the functions of macrophages/dendritic cells and promoting apoptosis/necrosis. Additionally, it has been found in fibrotic regions co-localiz...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248204/ https://www.ncbi.nlm.nih.gov/pubmed/32508664 http://dx.doi.org/10.3389/fphys.2020.00403 |
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author | Farini, Andrea Villa, Chiara Di Silvestre, Dario Bella, Pamela Tripodi, Luana Rossi, Rossana Sitzia, Clementina Gatti, Stefano Mauri, Pierluigi Torrente, Yvan |
author_facet | Farini, Andrea Villa, Chiara Di Silvestre, Dario Bella, Pamela Tripodi, Luana Rossi, Rossana Sitzia, Clementina Gatti, Stefano Mauri, Pierluigi Torrente, Yvan |
author_sort | Farini, Andrea |
collection | PubMed |
description | Pentraxin 3 (PTX3) is a main component of the innate immune system by inducing complement pathway activation, acting as an inflammatory mediator, coordinating the functions of macrophages/dendritic cells and promoting apoptosis/necrosis. Additionally, it has been found in fibrotic regions co-localizing with collagen. In this work, we wanted to investigate the predictive role of PTX3 in myocardial damage and fibrosis of Duchenne muscular dystrophy (DMD). DMD is an X-linked recessive disease caused by mutations of the dystrophin gene that affects muscular functions and strength and accompanying dilated cardiomyopathy. Here, we expound the correlation of PTX3 cardiac expression with age and Toll-like receptors (TLRs)/interleukin-1 receptor (IL-1R)-MyD88 inflammatory markers and its modulation by the so-called alarmins IL-33, high-mobility group box 1 (HMGB1), and S100β. These findings suggest that cardiac levels of PTX3 might have prognostic value and potential in guiding therapy for DMD cardiomyopathy. |
format | Online Article Text |
id | pubmed-7248204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72482042020-06-05 PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy Farini, Andrea Villa, Chiara Di Silvestre, Dario Bella, Pamela Tripodi, Luana Rossi, Rossana Sitzia, Clementina Gatti, Stefano Mauri, Pierluigi Torrente, Yvan Front Physiol Physiology Pentraxin 3 (PTX3) is a main component of the innate immune system by inducing complement pathway activation, acting as an inflammatory mediator, coordinating the functions of macrophages/dendritic cells and promoting apoptosis/necrosis. Additionally, it has been found in fibrotic regions co-localizing with collagen. In this work, we wanted to investigate the predictive role of PTX3 in myocardial damage and fibrosis of Duchenne muscular dystrophy (DMD). DMD is an X-linked recessive disease caused by mutations of the dystrophin gene that affects muscular functions and strength and accompanying dilated cardiomyopathy. Here, we expound the correlation of PTX3 cardiac expression with age and Toll-like receptors (TLRs)/interleukin-1 receptor (IL-1R)-MyD88 inflammatory markers and its modulation by the so-called alarmins IL-33, high-mobility group box 1 (HMGB1), and S100β. These findings suggest that cardiac levels of PTX3 might have prognostic value and potential in guiding therapy for DMD cardiomyopathy. Frontiers Media S.A. 2020-05-19 /pmc/articles/PMC7248204/ /pubmed/32508664 http://dx.doi.org/10.3389/fphys.2020.00403 Text en Copyright © 2020 Farini, Villa, Di Silvestre, Bella, Tripodi, Rossi, Sitzia, Gatti, Mauri and Torrente. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Farini, Andrea Villa, Chiara Di Silvestre, Dario Bella, Pamela Tripodi, Luana Rossi, Rossana Sitzia, Clementina Gatti, Stefano Mauri, Pierluigi Torrente, Yvan PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy |
title | PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy |
title_full | PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy |
title_fullStr | PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy |
title_full_unstemmed | PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy |
title_short | PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy |
title_sort | ptx3 predicts myocardial damage and fibrosis in duchenne muscular dystrophy |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248204/ https://www.ncbi.nlm.nih.gov/pubmed/32508664 http://dx.doi.org/10.3389/fphys.2020.00403 |
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