Cargando…

Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study

Objective: We investigated cerebral opioid receptor binding potential in patients with fibromyalgia syndrome (FMS) using positron-emission-tomography (PET) and correlated our results with patients’ systemic interleukin-4 (IL-4) gene expression. Methods: In this pilot study, seven FMS patients (1 man...

Descripción completa

Detalles Bibliográficos
Autores principales: Üçeyler, Nurcan, Buchholz, Hans-Georg, Kewenig, Susanne, Ament, Stephan-Johann, Birklein, Frank, Schreckenberger, Mathias, Sommer, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248364/
https://www.ncbi.nlm.nih.gov/pubmed/32508586
http://dx.doi.org/10.3389/fnins.2020.00512
_version_ 1783538356434501632
author Üçeyler, Nurcan
Buchholz, Hans-Georg
Kewenig, Susanne
Ament, Stephan-Johann
Birklein, Frank
Schreckenberger, Mathias
Sommer, Claudia
author_facet Üçeyler, Nurcan
Buchholz, Hans-Georg
Kewenig, Susanne
Ament, Stephan-Johann
Birklein, Frank
Schreckenberger, Mathias
Sommer, Claudia
author_sort Üçeyler, Nurcan
collection PubMed
description Objective: We investigated cerebral opioid receptor binding potential in patients with fibromyalgia syndrome (FMS) using positron-emission-tomography (PET) and correlated our results with patients’ systemic interleukin-4 (IL-4) gene expression. Methods: In this pilot study, seven FMS patients (1 man, 6 women) agreed to participate in experimental PET scans. All patients underwent neurological examination, were investigated with questionnaires for pain, depression, and FMS symptoms. Additionally, blood for IL-4 gene expression analysis was withdrawn at two time points with a median latency of 1.3 years. Patients were investigated in a PET scanner using the opioid receptor ligand F-18-fluoro-ethyl-diprenorphine ([18F]FEDPN) and results were compared with laboratory normative values. Results: Neurological examination was normal in all FMS patients. Reduced opioid receptor binding was found in mid cingulate cortex compared to healthy controls (p < 0.005). Interestingly, three patients with high systemic IL-4 gene expression had increased opioid receptor binding in the fronto-basal cortex compared to those with low IL-4 gene expression (p < 0.005). Conclusion: Our data give further evidence for a reduction in cortical opioid receptor availability in FMS patients as another potential central nervous system contributor to pain in FMS.
format Online
Article
Text
id pubmed-7248364
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-72483642020-06-05 Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study Üçeyler, Nurcan Buchholz, Hans-Georg Kewenig, Susanne Ament, Stephan-Johann Birklein, Frank Schreckenberger, Mathias Sommer, Claudia Front Neurosci Neuroscience Objective: We investigated cerebral opioid receptor binding potential in patients with fibromyalgia syndrome (FMS) using positron-emission-tomography (PET) and correlated our results with patients’ systemic interleukin-4 (IL-4) gene expression. Methods: In this pilot study, seven FMS patients (1 man, 6 women) agreed to participate in experimental PET scans. All patients underwent neurological examination, were investigated with questionnaires for pain, depression, and FMS symptoms. Additionally, blood for IL-4 gene expression analysis was withdrawn at two time points with a median latency of 1.3 years. Patients were investigated in a PET scanner using the opioid receptor ligand F-18-fluoro-ethyl-diprenorphine ([18F]FEDPN) and results were compared with laboratory normative values. Results: Neurological examination was normal in all FMS patients. Reduced opioid receptor binding was found in mid cingulate cortex compared to healthy controls (p < 0.005). Interestingly, three patients with high systemic IL-4 gene expression had increased opioid receptor binding in the fronto-basal cortex compared to those with low IL-4 gene expression (p < 0.005). Conclusion: Our data give further evidence for a reduction in cortical opioid receptor availability in FMS patients as another potential central nervous system contributor to pain in FMS. Frontiers Media S.A. 2020-05-19 /pmc/articles/PMC7248364/ /pubmed/32508586 http://dx.doi.org/10.3389/fnins.2020.00512 Text en Copyright © 2020 Üçeyler, Buchholz, Kewenig, Ament, Birklein, Schreckenberger and Sommer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Üçeyler, Nurcan
Buchholz, Hans-Georg
Kewenig, Susanne
Ament, Stephan-Johann
Birklein, Frank
Schreckenberger, Mathias
Sommer, Claudia
Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study
title Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study
title_full Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study
title_fullStr Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study
title_full_unstemmed Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study
title_short Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels – A Pilot Study
title_sort cortical binding potential of opioid receptors in patients with fibromyalgia syndrome and reduced systemic interleukin-4 levels – a pilot study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248364/
https://www.ncbi.nlm.nih.gov/pubmed/32508586
http://dx.doi.org/10.3389/fnins.2020.00512
work_keys_str_mv AT uceylernurcan corticalbindingpotentialofopioidreceptorsinpatientswithfibromyalgiasyndromeandreducedsystemicinterleukin4levelsapilotstudy
AT buchholzhansgeorg corticalbindingpotentialofopioidreceptorsinpatientswithfibromyalgiasyndromeandreducedsystemicinterleukin4levelsapilotstudy
AT kewenigsusanne corticalbindingpotentialofopioidreceptorsinpatientswithfibromyalgiasyndromeandreducedsystemicinterleukin4levelsapilotstudy
AT amentstephanjohann corticalbindingpotentialofopioidreceptorsinpatientswithfibromyalgiasyndromeandreducedsystemicinterleukin4levelsapilotstudy
AT birkleinfrank corticalbindingpotentialofopioidreceptorsinpatientswithfibromyalgiasyndromeandreducedsystemicinterleukin4levelsapilotstudy
AT schreckenbergermathias corticalbindingpotentialofopioidreceptorsinpatientswithfibromyalgiasyndromeandreducedsystemicinterleukin4levelsapilotstudy
AT sommerclaudia corticalbindingpotentialofopioidreceptorsinpatientswithfibromyalgiasyndromeandreducedsystemicinterleukin4levelsapilotstudy