Cargando…

Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings

Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the assessment of therapeutic response in patients with choroidal melanoma treated with brachytherapy. Materials and Methods: We performed a prospective, unicentric study which included patients with choroidal...

Descripción completa

Detalles Bibliográficos
Autores principales: Bitencourt, Flávia B. C. S. N., Bitencourt, Almir G. V., Chojniak, Martha M. M., Souza, Juliana O., Castro, Douglas G., Pellizzon, Antônio Cassio A., Chojniak, Rubens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248391/
https://www.ncbi.nlm.nih.gov/pubmed/32509587
http://dx.doi.org/10.3389/fonc.2020.00825
_version_ 1783538362794115072
author Bitencourt, Flávia B. C. S. N.
Bitencourt, Almir G. V.
Chojniak, Martha M. M.
Souza, Juliana O.
Castro, Douglas G.
Pellizzon, Antônio Cassio A.
Chojniak, Rubens
author_facet Bitencourt, Flávia B. C. S. N.
Bitencourt, Almir G. V.
Chojniak, Martha M. M.
Souza, Juliana O.
Castro, Douglas G.
Pellizzon, Antônio Cassio A.
Chojniak, Rubens
author_sort Bitencourt, Flávia B. C. S. N.
collection PubMed
description Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the assessment of therapeutic response in patients with choroidal melanoma treated with brachytherapy. Materials and Methods: We performed a prospective, unicentric study which included patients with choroidal melanoma and indication for brachytherapy. Three DW-MRI examinations were proposed for each patient, one before and two after treatment. The apparent diffusion coefficient (ADC) value was calculated on DW-MRI and compared with local tumor control assessed by ophthalmologic follow-up. Results: From 07/2018 to 06/2019, 19 patients were recruited, 13 of whom underwent follow-up examinations. Patients' ages ranged from 24 to 78 years and 52.9% were male. At the ocular ultrasound, the mean tumor thickness and diameter were 6.3 and 11.5 mm, respectively. Two patients (15.4%) showed signs of tumor progression during follow-up (7 and 9 months after treatment). There was no statistically significant difference in tumor size between MR before and after treatment, however, there was a significant reduction in mean ADC in patients with progression (p = 0.02). Conclusion: DW-MRI is a promising method for monitoring patients with choroidal melanoma; reduction in the mean ADC values between pre-treatment MRI and the first post-treatment MRI may be related to the lack of response to brachytherapy and increased risk of disease progression.
format Online
Article
Text
id pubmed-7248391
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-72483912020-06-05 Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings Bitencourt, Flávia B. C. S. N. Bitencourt, Almir G. V. Chojniak, Martha M. M. Souza, Juliana O. Castro, Douglas G. Pellizzon, Antônio Cassio A. Chojniak, Rubens Front Oncol Oncology Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the assessment of therapeutic response in patients with choroidal melanoma treated with brachytherapy. Materials and Methods: We performed a prospective, unicentric study which included patients with choroidal melanoma and indication for brachytherapy. Three DW-MRI examinations were proposed for each patient, one before and two after treatment. The apparent diffusion coefficient (ADC) value was calculated on DW-MRI and compared with local tumor control assessed by ophthalmologic follow-up. Results: From 07/2018 to 06/2019, 19 patients were recruited, 13 of whom underwent follow-up examinations. Patients' ages ranged from 24 to 78 years and 52.9% were male. At the ocular ultrasound, the mean tumor thickness and diameter were 6.3 and 11.5 mm, respectively. Two patients (15.4%) showed signs of tumor progression during follow-up (7 and 9 months after treatment). There was no statistically significant difference in tumor size between MR before and after treatment, however, there was a significant reduction in mean ADC in patients with progression (p = 0.02). Conclusion: DW-MRI is a promising method for monitoring patients with choroidal melanoma; reduction in the mean ADC values between pre-treatment MRI and the first post-treatment MRI may be related to the lack of response to brachytherapy and increased risk of disease progression. Frontiers Media S.A. 2020-05-19 /pmc/articles/PMC7248391/ /pubmed/32509587 http://dx.doi.org/10.3389/fonc.2020.00825 Text en Copyright © 2020 Bitencourt, Bitencourt, Chojniak, Souza, Castro, Pellizzon and Chojniak. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bitencourt, Flávia B. C. S. N.
Bitencourt, Almir G. V.
Chojniak, Martha M. M.
Souza, Juliana O.
Castro, Douglas G.
Pellizzon, Antônio Cassio A.
Chojniak, Rubens
Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings
title Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings
title_full Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings
title_fullStr Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings
title_full_unstemmed Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings
title_short Response Evaluation of Choroidal Melanoma After Brachytherapy Using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI): Preliminary Findings
title_sort response evaluation of choroidal melanoma after brachytherapy using diffusion-weighted magnetic resonance imaging (dw-mri): preliminary findings
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248391/
https://www.ncbi.nlm.nih.gov/pubmed/32509587
http://dx.doi.org/10.3389/fonc.2020.00825
work_keys_str_mv AT bitencourtflaviabcsn responseevaluationofchoroidalmelanomaafterbrachytherapyusingdiffusionweightedmagneticresonanceimagingdwmripreliminaryfindings
AT bitencourtalmirgv responseevaluationofchoroidalmelanomaafterbrachytherapyusingdiffusionweightedmagneticresonanceimagingdwmripreliminaryfindings
AT chojniakmarthamm responseevaluationofchoroidalmelanomaafterbrachytherapyusingdiffusionweightedmagneticresonanceimagingdwmripreliminaryfindings
AT souzajulianao responseevaluationofchoroidalmelanomaafterbrachytherapyusingdiffusionweightedmagneticresonanceimagingdwmripreliminaryfindings
AT castrodouglasg responseevaluationofchoroidalmelanomaafterbrachytherapyusingdiffusionweightedmagneticresonanceimagingdwmripreliminaryfindings
AT pellizzonantoniocassioa responseevaluationofchoroidalmelanomaafterbrachytherapyusingdiffusionweightedmagneticresonanceimagingdwmripreliminaryfindings
AT chojniakrubens responseevaluationofchoroidalmelanomaafterbrachytherapyusingdiffusionweightedmagneticresonanceimagingdwmripreliminaryfindings