PNU282987 inhibits amyloid-β aggregation by upregulating astrocytic endogenous αB-crystallin and HSP-70 via regulation of the α7AChR, PI3K/Akt/HSF-1 signaling axis

Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder. Abnormal aggregation of the neurotoxic amyloid-β (Aβ) peptide is an early event in AD. The activation of astrocytic α7 nicotinic acetylcholine receptor (α7 nAChR) can inhibit Aβ aggregation; thus, the molecular m...

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Detalles Bibliográficos
Autores principales: Ren, Zhenkui, Dong, Zhihui, Xie, Peng, Lv, Ju, Hu, Yumei, Guan, Zhizhong, Zhang, Chunlin, Yu, Wenfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248489/
https://www.ncbi.nlm.nih.gov/pubmed/32377707
http://dx.doi.org/10.3892/mmr.2020.11132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248489/
https://www.ncbi.nlm.nih.gov/pubmed/32377707
http://dx.doi.org/10.3892/mmr.2020.11132

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