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Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies

INTRODUCTION: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen independentl...

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Detalles Bibliográficos
Autores principales:	Picanço-Castro, Virgínia, Moço, Pablo Diego, Mizukami, Amanda, Vaz, Leticia Delfini, de Souza Fernandes Pereira, Marcelo, Silvestre, Renata Nacasaki, de Azevedo, Júlia Teixeira Cottas, de Sousa Bomfim, Aline, de Abreu Neto, Mario Soares, Malmegrim, Kelen Cristina Ribeiro, Swiech, Kamilla, Covas, Dimas Tadeu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Hematologia e Hemoterapia 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248496/ https://www.ncbi.nlm.nih.gov/pubmed/31676276 http://dx.doi.org/10.1016/j.htct.2019.06.007

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