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Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
Sickle cell anemia (SCA) is a common genetic blood disorder, affecting millions worldwide. According to current evidence, individuals with SCA have more than 300 times greater risk to develop bacterial meningitis (BM) than the general population. Herein we have described the characteristics of a ser...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Hematologia e Hemoterapia
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248505/ https://www.ncbi.nlm.nih.gov/pubmed/31806417 http://dx.doi.org/10.1016/j.htct.2019.06.006 |
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author | Chenou, Francine Azevedo, Jailton Leal, Helena Ferreira Gonçalves, Marilda de Souza Reis, Joice Neves |
author_facet | Chenou, Francine Azevedo, Jailton Leal, Helena Ferreira Gonçalves, Marilda de Souza Reis, Joice Neves |
author_sort | Chenou, Francine |
collection | PubMed |
description | Sickle cell anemia (SCA) is a common genetic blood disorder, affecting millions worldwide. According to current evidence, individuals with SCA have more than 300 times greater risk to develop bacterial meningitis (BM) than the general population. Herein we have described the characteristics of a series of BM cases in SCA patients in Salvador, Brazil, during 13 years of hospital-based surveillance. Data on clinical presentation, laboratory parameters and outcomes were collected retrospectively by reviewing medical records. From 1999 to 2011, ten SCA patients were identified among the 2511 cases of BM (10/2511; 0.40%). These patients were more likely to be male (90%) and to be younger (median age 8.5 years). The causative agents were Streptococcus pneumoniae (n = 5) and Haemophilus influenzae (n = 1). The most frequent pneumococcal serotypes were 23 F (2 cases), 14, 18 F, 23B (one case each). Common medical complications were stroke (n = 3); heart failure (n = 2), respiratory problems (n = 2), renal dysfunctions (n = 2) and leg ulcers (n = 1). This study highlights the importance of S. pneumoniae as a causative agent of meningitis in individuals with SCA and shows the diversity of comorbidities associated with this condition. |
format | Online Article Text |
id | pubmed-7248505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedade Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-72485052020-05-29 Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases Chenou, Francine Azevedo, Jailton Leal, Helena Ferreira Gonçalves, Marilda de Souza Reis, Joice Neves Hematol Transfus Cell Ther Original Article Sickle cell anemia (SCA) is a common genetic blood disorder, affecting millions worldwide. According to current evidence, individuals with SCA have more than 300 times greater risk to develop bacterial meningitis (BM) than the general population. Herein we have described the characteristics of a series of BM cases in SCA patients in Salvador, Brazil, during 13 years of hospital-based surveillance. Data on clinical presentation, laboratory parameters and outcomes were collected retrospectively by reviewing medical records. From 1999 to 2011, ten SCA patients were identified among the 2511 cases of BM (10/2511; 0.40%). These patients were more likely to be male (90%) and to be younger (median age 8.5 years). The causative agents were Streptococcus pneumoniae (n = 5) and Haemophilus influenzae (n = 1). The most frequent pneumococcal serotypes were 23 F (2 cases), 14, 18 F, 23B (one case each). Common medical complications were stroke (n = 3); heart failure (n = 2), respiratory problems (n = 2), renal dysfunctions (n = 2) and leg ulcers (n = 1). This study highlights the importance of S. pneumoniae as a causative agent of meningitis in individuals with SCA and shows the diversity of comorbidities associated with this condition. Sociedade Brasileira de Hematologia e Hemoterapia 2020 2019-09-20 /pmc/articles/PMC7248505/ /pubmed/31806417 http://dx.doi.org/10.1016/j.htct.2019.06.006 Text en © 2019 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Chenou, Francine Azevedo, Jailton Leal, Helena Ferreira Gonçalves, Marilda de Souza Reis, Joice Neves Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases |
title | Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases |
title_full | Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases |
title_fullStr | Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases |
title_full_unstemmed | Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases |
title_short | Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases |
title_sort | bacterial meningitis in patients with sickle cell anemia in salvador, bahia, brazil: a report on ten cases |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248505/ https://www.ncbi.nlm.nih.gov/pubmed/31806417 http://dx.doi.org/10.1016/j.htct.2019.06.006 |
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