Cargando…

Next Generation Methods for Single-Molecule Force Spectroscopy on Polyproteins and Receptor-Ligand Complexes

Single-molecule force spectroscopy with the atomic force microscope provides molecular level insights into protein function, allowing researchers to reconstruct energy landscapes and understand functional mechanisms in biology. With steadily advancing methods, this technique has greatly accelerated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Byeongseon, Liu, Zhaowei, Liu, Haipei, Nash, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248566/ https://www.ncbi.nlm.nih.gov/pubmed/32509800 http://dx.doi.org/10.3389/fmolb.2020.00085

Ejemplares similares

Optimal Sacrificial Domains in Mechanical Polyproteins: S. epidermidis Adhesins Are Tuned for Work Dissipation
por: Liu, Haipei, et al.
Publicado: (2022)

Influence of Fluorination on Single-Molecule Unfolding and Rupture Pathways of a Mechanostable Protein Adhesion Complex
por: Yang, Byeongseon, et al.
Publicado: (2020)

Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy
por: Zhu, Rong, et al.
Publicado: (2020)

Improving Small-Molecule Force Field Parameters in Ligand Binding Studies
por: Raniolo, Stefano, et al.
Publicado: (2021)

Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs
por: Giddens, John P., et al.
Publicado: (2022)

Quantum-based machine learning and AI models to generate force field parameters for drug-like small molecules
por: Mudedla, Sathish Kumar, et al.
Publicado: (2022)

Editorial: Interactions Between Small Molecule Ligands and Target Enzymes
por: Kim, Sung-Kun, et al.
Publicado: (2021)

Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex
por: Liu, Zhaowei, et al.
Publicado: (2021)

Detection of Mosaic Variants in Mothers of MPS II Patients by Next Generation Sequencing
por: Oliveira Netto, Alice Brinckmann, et al.
Publicado: (2021)

Single-Molecule Insights Into the Dynamics of Replicative Helicases
por: Spinks, Richard R., et al.
Publicado: (2021)

Single Molecule Measurements of the Accessibility of Molecular Surfaces
por: Dey, Arpan, et al.
Publicado: (2021)

Contribution of Infrared Spectroscopy to the Understanding of Amyloid Protein Aggregation in Complex Systems
por: Ami, Diletta, et al.
Publicado: (2022)

From protein structure to function via single crystal optical spectroscopy
por: Ronda, Luca, et al.
Publicado: (2015)

Somatic Mutation Profiles Revealed by Next Generation Sequencing (NGS) in 39 Chinese Hepatocellular Carcinoma Patients
por: Ke, Lixin, et al.
Publicado: (2022)

Editorial: Surveying Life One Molecule at a Time: Single Molecule Methods Dig Deeper Into Contemporary Biology
por: Kim, Seong Ho, et al.
Publicado: (2022)

Searching for DNA Damage: Insights From Single Molecule Analysis
por: Schaich, Matthew A., et al.
Publicado: (2021)

Conformational Dynamics of DNA Polymerases Revealed at the Single-Molecule Level
por: Millar, David P.
Publicado: (2022)

Single-Molecule FRET: A Tool to Characterize DNA Nanostructures
por: Pal, Nibedita
Publicado: (2022)

Computational Study of PCSK9-EGFA Complex with Effective Polarizable Bond Force Field
por: Chen, Jian, et al.
Publicado: (2018)

The Influence of Some Axial Ligands on Ruthenium–Phthalocyanine Complexes: Chemical, Photochemical, and Photobiological Properties
por: Martins, Tássia Joi, et al.
Publicado: (2021)

Validation and Clinical Applications of a Comprehensive Next Generation Sequencing System for Molecular Characterization of Solid Cancer Tissues
por: Dehghani, Mehdi, et al.
Publicado: (2019)

Next-Generation Molecular Diagnostics Development by CRISPR/Cas Tool: Rapid Detection and Surveillance of Viral Disease Outbreaks
por: Srivastava, Sonal, et al.
Publicado: (2020)

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study
por: Arras, Paul, et al.
Publicado: (2023)

The Function of Membrane Integral Pyrophosphatases From Whole Organism to Single Molecule
por: Holmes, Alexandra O. M., et al.
Publicado: (2019)

On the use of thermal forces to probe kinesin’s response to force
por: Chang, Chuan, et al.
Publicado: (2023)

The Stoichiometric Interaction of the Hsp90-Sgt1-Rar1 Complex by CD and SRCD Spectroscopy
por: Siligardi, Giuliano, et al.
Publicado: (2018)

DFMD: Fast and Effective DelPhiForce Steered Molecular Dynamics Approach to Model Ligand Approach Toward a Receptor: Application to Spermine Synthase Enzyme
por: Peng, Yunhui, et al.
Publicado: (2019)

Determining Complex Structures using Docking Method with Single Particle Scattering Data
por: Wang, Hongxiao, et al.
Publicado: (2017)

Enhanced UnaG With Minimal Labeling Artifact for Single-Molecule Localization Microscopy
por: Ko, Sangyoon, et al.
Publicado: (2021)

Perspective: Structure determination of protein-ligand complexes at room temperature using X-ray diffraction approaches
por: Hough, Michael A., et al.
Publicado: (2023)

Dithiocarbazate ligands and their Ni(II) complexes with potential biological activity: Structural, antitumor and molecular docking study
por: Cavalcante, Cássia de Q. O., et al.
Publicado: (2023)

A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples
por: Ng, Cedric Chuan-Young, et al.
Publicado: (2022)

Erratum: DFMD: Fast and Effective DelPhiForce Steered Molecular Dynamics Approach to Model Ligand Approach Toward a Receptor: Application to Spermine Synthase Enzyme
Publicado: (2019)

A Toolbox for Site-Specific Labeling of RecQ Helicase With a Single Fluorophore Used in the Single-Molecule Assay
por: Teng, Fang-Yuan, et al.
Publicado: (2020)

Thermal titration molecular dynamics (TTMD): shedding light on the stability of RNA-small molecule complexes
por: Dodaro, Andrea, et al.
Publicado: (2023)

Single Molecule Study of the Polymerization of RecA on dsDNA: The Dynamics of Individual Domains
por: Maman, Nitzan, et al.
Publicado: (2021)

Single-molecule force spectroscopy of protein-membrane interactions
por: Ma, Lu, et al.
Publicado: (2017)

Critical roles of functional molecule metabolites
por: Liu, Peng, et al.
Publicado: (2023)

Decoding the Structural Dynamics and Conformational Alternations of DNA Secondary Structures by Single-Molecule FRET Microspectroscopy
por: Bandyopadhyay, Debolina, et al.
Publicado: (2021)

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
por: Koniuszewski, Filip, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jeshf8uhkgq83ke7vs85u535iu