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Modulation of Inflammation by Extracellular Granzyme A
Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current literature, accumulating evidence now indicates role...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248576/ https://www.ncbi.nlm.nih.gov/pubmed/32508827 http://dx.doi.org/10.3389/fimmu.2020.00931 |
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author | van Daalen, Kim R. Reijneveld, Josephine F. Bovenschen, Niels |
author_facet | van Daalen, Kim R. Reijneveld, Josephine F. Bovenschen, Niels |
author_sort | van Daalen, Kim R. |
collection | PubMed |
description | Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current literature, accumulating evidence now indicates roles for extracellular GrA in modulating inflammation and inflammatory diseases. This paper aims to explore the literature presenting current knowledge on GrA as an extracellular modulator of inflammation by summarizing (i) the presence and role of extracellular GrA in several inflammatory diseases, and (ii) the potential molecular mechanisms of extracellular GrA in augmenting inflammation. |
format | Online Article Text |
id | pubmed-7248576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72485762020-06-05 Modulation of Inflammation by Extracellular Granzyme A van Daalen, Kim R. Reijneveld, Josephine F. Bovenschen, Niels Front Immunol Immunology Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current literature, accumulating evidence now indicates roles for extracellular GrA in modulating inflammation and inflammatory diseases. This paper aims to explore the literature presenting current knowledge on GrA as an extracellular modulator of inflammation by summarizing (i) the presence and role of extracellular GrA in several inflammatory diseases, and (ii) the potential molecular mechanisms of extracellular GrA in augmenting inflammation. Frontiers Media S.A. 2020-05-19 /pmc/articles/PMC7248576/ /pubmed/32508827 http://dx.doi.org/10.3389/fimmu.2020.00931 Text en Copyright © 2020 van Daalen, Reijneveld and Bovenschen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology van Daalen, Kim R. Reijneveld, Josephine F. Bovenschen, Niels Modulation of Inflammation by Extracellular Granzyme A |
title | Modulation of Inflammation by Extracellular Granzyme A |
title_full | Modulation of Inflammation by Extracellular Granzyme A |
title_fullStr | Modulation of Inflammation by Extracellular Granzyme A |
title_full_unstemmed | Modulation of Inflammation by Extracellular Granzyme A |
title_short | Modulation of Inflammation by Extracellular Granzyme A |
title_sort | modulation of inflammation by extracellular granzyme a |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248576/ https://www.ncbi.nlm.nih.gov/pubmed/32508827 http://dx.doi.org/10.3389/fimmu.2020.00931 |
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