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Modulation of Inflammation by Extracellular Granzyme A

Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current literature, accumulating evidence now indicates role...

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Autores principales: van Daalen, Kim R., Reijneveld, Josephine F., Bovenschen, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248576/
https://www.ncbi.nlm.nih.gov/pubmed/32508827
http://dx.doi.org/10.3389/fimmu.2020.00931
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author van Daalen, Kim R.
Reijneveld, Josephine F.
Bovenschen, Niels
author_facet van Daalen, Kim R.
Reijneveld, Josephine F.
Bovenschen, Niels
author_sort van Daalen, Kim R.
collection PubMed
description Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current literature, accumulating evidence now indicates roles for extracellular GrA in modulating inflammation and inflammatory diseases. This paper aims to explore the literature presenting current knowledge on GrA as an extracellular modulator of inflammation by summarizing (i) the presence and role of extracellular GrA in several inflammatory diseases, and (ii) the potential molecular mechanisms of extracellular GrA in augmenting inflammation.
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spelling pubmed-72485762020-06-05 Modulation of Inflammation by Extracellular Granzyme A van Daalen, Kim R. Reijneveld, Josephine F. Bovenschen, Niels Front Immunol Immunology Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current literature, accumulating evidence now indicates roles for extracellular GrA in modulating inflammation and inflammatory diseases. This paper aims to explore the literature presenting current knowledge on GrA as an extracellular modulator of inflammation by summarizing (i) the presence and role of extracellular GrA in several inflammatory diseases, and (ii) the potential molecular mechanisms of extracellular GrA in augmenting inflammation. Frontiers Media S.A. 2020-05-19 /pmc/articles/PMC7248576/ /pubmed/32508827 http://dx.doi.org/10.3389/fimmu.2020.00931 Text en Copyright © 2020 van Daalen, Reijneveld and Bovenschen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
van Daalen, Kim R.
Reijneveld, Josephine F.
Bovenschen, Niels
Modulation of Inflammation by Extracellular Granzyme A
title Modulation of Inflammation by Extracellular Granzyme A
title_full Modulation of Inflammation by Extracellular Granzyme A
title_fullStr Modulation of Inflammation by Extracellular Granzyme A
title_full_unstemmed Modulation of Inflammation by Extracellular Granzyme A
title_short Modulation of Inflammation by Extracellular Granzyme A
title_sort modulation of inflammation by extracellular granzyme a
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248576/
https://www.ncbi.nlm.nih.gov/pubmed/32508827
http://dx.doi.org/10.3389/fimmu.2020.00931
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