Investigation of a Lomentospora prolificans case cluster with whole genome sequencing

Lomentospora prolificans has caused outbreaks in immunocompromised patients. We performed whole genome sequencing (WGS) on 4 L. prolificans isolates from infections occurring during an 8-month period in the haematology unit at Hospital 1., and 2 isolates from unrelated infections at Hospital 2., sho...

Descripción completa

Detalles Bibliográficos
Autores principales: Boan, Peter, Pang, Stanley, Gardam, Dianne J., Darragh, Helen, Wright, Matthew, Coombs, Geoffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248584/
https://www.ncbi.nlm.nih.gov/pubmed/32477857
http://dx.doi.org/10.1016/j.mmcr.2020.05.003
_version_ 1783538406599426048
author Boan, Peter
Pang, Stanley
Gardam, Dianne J.
Darragh, Helen
Wright, Matthew
Coombs, Geoffrey W.
author_facet Boan, Peter
Pang, Stanley
Gardam, Dianne J.
Darragh, Helen
Wright, Matthew
Coombs, Geoffrey W.
author_sort Boan, Peter
collection PubMed
description Lomentospora prolificans has caused outbreaks in immunocompromised patients. We performed whole genome sequencing (WGS) on 4 L. prolificans isolates from infections occurring during an 8-month period in the haematology unit at Hospital 1., and 2 isolates from unrelated infections at Hospital 2., showing a high number of mutational differences (>10,000 single nucleotide polymorphisms) between L. prolificans isolates from Hospital 1. Novel typing of isolates by WGS did not demonstrate a single causative strain.
format Online
Article
Text
id pubmed-7248584
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-72485842020-05-29 Investigation of a Lomentospora prolificans case cluster with whole genome sequencing Boan, Peter Pang, Stanley Gardam, Dianne J. Darragh, Helen Wright, Matthew Coombs, Geoffrey W. Med Mycol Case Rep Case Series Lomentospora prolificans has caused outbreaks in immunocompromised patients. We performed whole genome sequencing (WGS) on 4 L. prolificans isolates from infections occurring during an 8-month period in the haematology unit at Hospital 1., and 2 isolates from unrelated infections at Hospital 2., showing a high number of mutational differences (>10,000 single nucleotide polymorphisms) between L. prolificans isolates from Hospital 1. Novel typing of isolates by WGS did not demonstrate a single causative strain. Elsevier 2020-05-19 /pmc/articles/PMC7248584/ /pubmed/32477857 http://dx.doi.org/10.1016/j.mmcr.2020.05.003 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Series
Boan, Peter
Pang, Stanley
Gardam, Dianne J.
Darragh, Helen
Wright, Matthew
Coombs, Geoffrey W.
Investigation of a Lomentospora prolificans case cluster with whole genome sequencing
title Investigation of a Lomentospora prolificans case cluster with whole genome sequencing
title_full Investigation of a Lomentospora prolificans case cluster with whole genome sequencing
title_fullStr Investigation of a Lomentospora prolificans case cluster with whole genome sequencing
title_full_unstemmed Investigation of a Lomentospora prolificans case cluster with whole genome sequencing
title_short Investigation of a Lomentospora prolificans case cluster with whole genome sequencing
title_sort investigation of a lomentospora prolificans case cluster with whole genome sequencing
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248584/
https://www.ncbi.nlm.nih.gov/pubmed/32477857
http://dx.doi.org/10.1016/j.mmcr.2020.05.003
work_keys_str_mv AT boanpeter investigationofalomentosporaprolificanscaseclusterwithwholegenomesequencing
AT pangstanley investigationofalomentosporaprolificanscaseclusterwithwholegenomesequencing
AT gardamdiannej investigationofalomentosporaprolificanscaseclusterwithwholegenomesequencing
AT darraghhelen investigationofalomentosporaprolificanscaseclusterwithwholegenomesequencing
AT wrightmatthew investigationofalomentosporaprolificanscaseclusterwithwholegenomesequencing
AT coombsgeoffreyw investigationofalomentosporaprolificanscaseclusterwithwholegenomesequencing

Ejemplares similares