SPOP promotes ubiquitination and degradation of LATS1 to enhance kidney cancer progression

BACKGROUND: Emerging evidence has demonstrated that SPOP functions as an oncoprotein in kidney cancer to promote tumorigenesis by ubiquitination-mediated degradation of multiple regulators of cellular proliferation and apoptosis. However, the detailed molecular mechanism underlying the oncogenic rol...

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Detalles Bibliográficos
Autores principales: Wang, Lixia, Lin, Min, Chu, Man, Liu, Yi, Ma, Jia, He, Youhua, Wang, Zhi-wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248661/
https://www.ncbi.nlm.nih.gov/pubmed/32460168
http://dx.doi.org/10.1016/j.ebiom.2020.102795

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