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IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms

The clinical symptoms of prediabetes are mild and easy to overlook, but prediabetes may develop into diabetes if early intervention is not performed. In this study, a deep learning model—referred to as IGRNet—is developed to effectively detect and diagnose prediabetes in a non-invasive, real-time ma...

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Detalles Bibliográficos
Autores principales: Wang, Liyang, Mu, Yao, Zhao, Jing, Wang, Xiaoya, Che, Huilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248708/
https://www.ncbi.nlm.nih.gov/pubmed/32365875
http://dx.doi.org/10.3390/s20092556
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author Wang, Liyang
Mu, Yao
Zhao, Jing
Wang, Xiaoya
Che, Huilian
author_facet Wang, Liyang
Mu, Yao
Zhao, Jing
Wang, Xiaoya
Che, Huilian
author_sort Wang, Liyang
collection PubMed
description The clinical symptoms of prediabetes are mild and easy to overlook, but prediabetes may develop into diabetes if early intervention is not performed. In this study, a deep learning model—referred to as IGRNet—is developed to effectively detect and diagnose prediabetes in a non-invasive, real-time manner using a 12-lead electrocardiogram (ECG) lasting 5 s. After searching for an appropriate activation function, we compared two mainstream deep neural networks (AlexNet and GoogLeNet) and three traditional machine learning algorithms to verify the superiority of our method. The diagnostic accuracy of IGRNet is 0.781, and the area under the receiver operating characteristic curve (AUC) is 0.777 after testing on the independent test set including mixed group. Furthermore, the accuracy and AUC are 0.856 and 0.825, respectively, in the normal-weight-range test set. The experimental results indicate that IGRNet diagnoses prediabetes with high accuracy using ECGs, outperforming existing other machine learning methods; this suggests its potential for application in clinical practice as a non-invasive, prediabetes diagnosis technology.
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spelling pubmed-72487082020-08-13 IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms Wang, Liyang Mu, Yao Zhao, Jing Wang, Xiaoya Che, Huilian Sensors (Basel) Article The clinical symptoms of prediabetes are mild and easy to overlook, but prediabetes may develop into diabetes if early intervention is not performed. In this study, a deep learning model—referred to as IGRNet—is developed to effectively detect and diagnose prediabetes in a non-invasive, real-time manner using a 12-lead electrocardiogram (ECG) lasting 5 s. After searching for an appropriate activation function, we compared two mainstream deep neural networks (AlexNet and GoogLeNet) and three traditional machine learning algorithms to verify the superiority of our method. The diagnostic accuracy of IGRNet is 0.781, and the area under the receiver operating characteristic curve (AUC) is 0.777 after testing on the independent test set including mixed group. Furthermore, the accuracy and AUC are 0.856 and 0.825, respectively, in the normal-weight-range test set. The experimental results indicate that IGRNet diagnoses prediabetes with high accuracy using ECGs, outperforming existing other machine learning methods; this suggests its potential for application in clinical practice as a non-invasive, prediabetes diagnosis technology. MDPI 2020-04-30 /pmc/articles/PMC7248708/ /pubmed/32365875 http://dx.doi.org/10.3390/s20092556 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Liyang
Mu, Yao
Zhao, Jing
Wang, Xiaoya
Che, Huilian
IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms
title IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms
title_full IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms
title_fullStr IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms
title_full_unstemmed IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms
title_short IGRNet: A Deep Learning Model for Non-Invasive, Real-Time Diagnosis of Prediabetes through Electrocardiograms
title_sort igrnet: a deep learning model for non-invasive, real-time diagnosis of prediabetes through electrocardiograms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248708/
https://www.ncbi.nlm.nih.gov/pubmed/32365875
http://dx.doi.org/10.3390/s20092556
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