Cargando…

The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature

Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until i...

Descripción completa

Detalles Bibliográficos
Autores principales: Ostróżka-Cieślik, Aneta, Dolińska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248710/
https://www.ncbi.nlm.nih.gov/pubmed/32392782
http://dx.doi.org/10.3390/molecules25092185
_version_ 1783538433461846016
author Ostróżka-Cieślik, Aneta
Dolińska, Barbara
author_facet Ostróżka-Cieślik, Aneta
Dolińska, Barbara
author_sort Ostróżka-Cieślik, Aneta
collection PubMed
description Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until implantation into the recipient. Optimizations are mostly based on commercial solutions, routinely used to store grafts intended for transplantation. The paper reviews hormones with a potential nephroprotective effect, which were used to modify the composition of renal perfusion and preservation solutions. Their effectiveness as ingredients of preservation solutions was analysed based on a literature review. Hormones and trophic factors are innovative preservation solution supplements. They have a pleiotropic effect and affect normal renal function. The expression of receptors for melatonin, prolactin, thyrotropin, corticotropin, prostaglandin E1 and trophic factors was confirmed in the kidneys, which suggests that they are a promising therapeutic target for renal IR (ischemia-reperfusion) injury. They can have anti-inflammatory, antioxidant and anti-apoptotic effects, limiting IR injury.
format Online
Article
Text
id pubmed-7248710
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72487102020-08-13 The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature Ostróżka-Cieślik, Aneta Dolińska, Barbara Molecules Review Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until implantation into the recipient. Optimizations are mostly based on commercial solutions, routinely used to store grafts intended for transplantation. The paper reviews hormones with a potential nephroprotective effect, which were used to modify the composition of renal perfusion and preservation solutions. Their effectiveness as ingredients of preservation solutions was analysed based on a literature review. Hormones and trophic factors are innovative preservation solution supplements. They have a pleiotropic effect and affect normal renal function. The expression of receptors for melatonin, prolactin, thyrotropin, corticotropin, prostaglandin E1 and trophic factors was confirmed in the kidneys, which suggests that they are a promising therapeutic target for renal IR (ischemia-reperfusion) injury. They can have anti-inflammatory, antioxidant and anti-apoptotic effects, limiting IR injury. MDPI 2020-05-07 /pmc/articles/PMC7248710/ /pubmed/32392782 http://dx.doi.org/10.3390/molecules25092185 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ostróżka-Cieślik, Aneta
Dolińska, Barbara
The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
title The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
title_full The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
title_fullStr The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
title_full_unstemmed The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
title_short The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
title_sort role of hormones and trophic factors as components of preservation solutions in protection of renal function before transplantation: a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248710/
https://www.ncbi.nlm.nih.gov/pubmed/32392782
http://dx.doi.org/10.3390/molecules25092185
work_keys_str_mv AT ostrozkacieslikaneta theroleofhormonesandtrophicfactorsascomponentsofpreservationsolutionsinprotectionofrenalfunctionbeforetransplantationareviewoftheliterature
AT dolinskabarbara theroleofhormonesandtrophicfactorsascomponentsofpreservationsolutionsinprotectionofrenalfunctionbeforetransplantationareviewoftheliterature
AT ostrozkacieslikaneta roleofhormonesandtrophicfactorsascomponentsofpreservationsolutionsinprotectionofrenalfunctionbeforetransplantationareviewoftheliterature
AT dolinskabarbara roleofhormonesandtrophicfactorsascomponentsofpreservationsolutionsinprotectionofrenalfunctionbeforetransplantationareviewoftheliterature