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Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products
We report an unprecedented multicomponent reaction of acetoacetanilide with malononitrile leading to a structurally novel bicyclic product (9) in a high yield. The structure has been confirmed by X-ray crystallography and comparative Hirshfeld surface analysis of 5-cyano-2-hydroxy-2-methyl-N-phenyl-...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248728/ https://www.ncbi.nlm.nih.gov/pubmed/32397450 http://dx.doi.org/10.3390/molecules25092235 |
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| author | Naghiyev, Farid N. Cisterna, Jonathan Khalilov, Ali N. Maharramov, Abel M. Askerov, Rizvan K. Asadov, Khammed A. Mamedov, Ibrahim G. Salmanli, Khaver S. Cárdenas, Alejandro Brito, Ivan |
| author_facet | Naghiyev, Farid N. Cisterna, Jonathan Khalilov, Ali N. Maharramov, Abel M. Askerov, Rizvan K. Asadov, Khammed A. Mamedov, Ibrahim G. Salmanli, Khaver S. Cárdenas, Alejandro Brito, Ivan |
| author_sort | Naghiyev, Farid N. |
| collection | PubMed |
| description | We report an unprecedented multicomponent reaction of acetoacetanilide with malononitrile leading to a structurally novel bicyclic product (9) in a high yield. The structure has been confirmed by X-ray crystallography and comparative Hirshfeld surface analysis of 5-cyano-2-hydroxy-2-methyl-N-phenyl-4-(yridine-4-yl)-6-(thiophen-2-yl)-3,4-dihydro-2H-pyran-3-carboxamide 2, 5-cyano-2-hydroxy-2-methyl-6-oxo-N-phenyl-4-(thiophen-2-yl)piperidine-3-carboxamide 4 and 2-(8-amino-7,8a-dicyano-1-imino-4a-methyl-3-oxo-2-phenyl-1,3,4,4a,5,8a-hexahydroisoquinolin-6(2H)-ylidene)-N-phenylacetamide 9. |
| format | Online Article Text |
| id | pubmed-7248728 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72487282020-08-13 Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products Naghiyev, Farid N. Cisterna, Jonathan Khalilov, Ali N. Maharramov, Abel M. Askerov, Rizvan K. Asadov, Khammed A. Mamedov, Ibrahim G. Salmanli, Khaver S. Cárdenas, Alejandro Brito, Ivan Molecules Article We report an unprecedented multicomponent reaction of acetoacetanilide with malononitrile leading to a structurally novel bicyclic product (9) in a high yield. The structure has been confirmed by X-ray crystallography and comparative Hirshfeld surface analysis of 5-cyano-2-hydroxy-2-methyl-N-phenyl-4-(yridine-4-yl)-6-(thiophen-2-yl)-3,4-dihydro-2H-pyran-3-carboxamide 2, 5-cyano-2-hydroxy-2-methyl-6-oxo-N-phenyl-4-(thiophen-2-yl)piperidine-3-carboxamide 4 and 2-(8-amino-7,8a-dicyano-1-imino-4a-methyl-3-oxo-2-phenyl-1,3,4,4a,5,8a-hexahydroisoquinolin-6(2H)-ylidene)-N-phenylacetamide 9. MDPI 2020-05-09 /pmc/articles/PMC7248728/ /pubmed/32397450 http://dx.doi.org/10.3390/molecules25092235 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Naghiyev, Farid N. Cisterna, Jonathan Khalilov, Ali N. Maharramov, Abel M. Askerov, Rizvan K. Asadov, Khammed A. Mamedov, Ibrahim G. Salmanli, Khaver S. Cárdenas, Alejandro Brito, Ivan Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products |
| title | Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products |
| title_full | Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products |
| title_fullStr | Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products |
| title_full_unstemmed | Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products |
| title_short | Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products |
| title_sort | crystal structure and hirshfeld surface analysis of acetoacetanilide based reaction products |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248728/ https://www.ncbi.nlm.nih.gov/pubmed/32397450 http://dx.doi.org/10.3390/molecules25092235 |
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