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Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview
In-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publication...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248733/ https://www.ncbi.nlm.nih.gov/pubmed/32365828 http://dx.doi.org/10.3390/molecules25092096 |
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author | Manousi, Natalia Tzanavaras, Paraskevas D. Zacharis, Constantinos K. |
author_facet | Manousi, Natalia Tzanavaras, Paraskevas D. Zacharis, Constantinos K. |
author_sort | Manousi, Natalia |
collection | PubMed |
description | In-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publications, as well as in the research groups focusing their activities on this technique. In the present review article, HPLC bioanalytical applications of in-tube SPME are discussed, covering a wide time frame of twenty years of research reports. Instrumental aspects towards the coupling of in-tube SPME and HPLC are also discussed, and detailed information on materials/coatings and applications in biological samples are provided. |
format | Online Article Text |
id | pubmed-7248733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72487332020-08-13 Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview Manousi, Natalia Tzanavaras, Paraskevas D. Zacharis, Constantinos K. Molecules Review In-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publications, as well as in the research groups focusing their activities on this technique. In the present review article, HPLC bioanalytical applications of in-tube SPME are discussed, covering a wide time frame of twenty years of research reports. Instrumental aspects towards the coupling of in-tube SPME and HPLC are also discussed, and detailed information on materials/coatings and applications in biological samples are provided. MDPI 2020-04-30 /pmc/articles/PMC7248733/ /pubmed/32365828 http://dx.doi.org/10.3390/molecules25092096 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Manousi, Natalia Tzanavaras, Paraskevas D. Zacharis, Constantinos K. Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
title | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
title_full | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
title_fullStr | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
title_full_unstemmed | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
title_short | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
title_sort | bioanalytical hplc applications of in-tube solid phase microextraction: a two-decade overview |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248733/ https://www.ncbi.nlm.nih.gov/pubmed/32365828 http://dx.doi.org/10.3390/molecules25092096 |
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