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Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules

Silver (Ag)-grafted PMA (poly-methacrylic acid, sodium salt) nanocomposite loaded with sorafenib tosylate (SFT), an anticancer drug, showed good capability as a drug carrier allowing on-demand control of the dose, timing and duration of the drug release by laser irradiation stimuli. In this study, t...

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Detalles Bibliográficos
Autores principales: Neri, Giulia, Corsaro, Carmelo, Fazio, Enza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248805/
https://www.ncbi.nlm.nih.gov/pubmed/32403460
http://dx.doi.org/10.3390/molecules25092267
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author Neri, Giulia
Corsaro, Carmelo
Fazio, Enza
author_facet Neri, Giulia
Corsaro, Carmelo
Fazio, Enza
author_sort Neri, Giulia
collection PubMed
description Silver (Ag)-grafted PMA (poly-methacrylic acid, sodium salt) nanocomposite loaded with sorafenib tosylate (SFT), an anticancer drug, showed good capability as a drug carrier allowing on-demand control of the dose, timing and duration of the drug release by laser irradiation stimuli. In this study, the preparation of Ag-PMA capsules loaded with SFT by using sacrificial silica microparticles as templates was reported. A high drug loading (DL%) of ∼13% and encapsulation efficiency (EE%) of about 76% were obtained. The photo-release profiles were regulated via the adjustment of light wavelength and power intensity. A significant improvement of SFT release (14% vs. 21%) by comparing SFT-Ag-PMA capsules with Ag-PMA colloids under the same experimental conditions was observed. Moreover, an increase of drug release by up to 35% was reached by tuning the laser irradiation wavelength near to Ag nanoparticles’ surface plasmon resonance (SPR). These experimental results together with more economical use of the active component suggest the potentiality of SFT-Ag-PMA capsules as a smart drug delivery system.
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spelling pubmed-72488052020-06-10 Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules Neri, Giulia Corsaro, Carmelo Fazio, Enza Molecules Article Silver (Ag)-grafted PMA (poly-methacrylic acid, sodium salt) nanocomposite loaded with sorafenib tosylate (SFT), an anticancer drug, showed good capability as a drug carrier allowing on-demand control of the dose, timing and duration of the drug release by laser irradiation stimuli. In this study, the preparation of Ag-PMA capsules loaded with SFT by using sacrificial silica microparticles as templates was reported. A high drug loading (DL%) of ∼13% and encapsulation efficiency (EE%) of about 76% were obtained. The photo-release profiles were regulated via the adjustment of light wavelength and power intensity. A significant improvement of SFT release (14% vs. 21%) by comparing SFT-Ag-PMA capsules with Ag-PMA colloids under the same experimental conditions was observed. Moreover, an increase of drug release by up to 35% was reached by tuning the laser irradiation wavelength near to Ag nanoparticles’ surface plasmon resonance (SPR). These experimental results together with more economical use of the active component suggest the potentiality of SFT-Ag-PMA capsules as a smart drug delivery system. MDPI 2020-05-11 /pmc/articles/PMC7248805/ /pubmed/32403460 http://dx.doi.org/10.3390/molecules25092267 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Neri, Giulia
Corsaro, Carmelo
Fazio, Enza
Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules
title Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules
title_full Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules
title_fullStr Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules
title_full_unstemmed Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules
title_short Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules
title_sort plasmon-enhanced controlled drug release from ag-pma capsules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248805/
https://www.ncbi.nlm.nih.gov/pubmed/32403460
http://dx.doi.org/10.3390/molecules25092267
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