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Smart Electronic Eyedrop Bottle for Unobtrusive Monitoring of Glaucoma Medication Adherence

Glaucoma, the leading cause of irreversible blindness, affects >70 million people worldwide. Lowering intraocular pressure via topical administration of eye drops is the most common first-line therapy for glaucoma. This treatment paradigm has notoriously high non-adherence rates: ranging from 30%...

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Autores principales: Aguilar-Rivera, Marcelo, Erudaitius, Dieanira T., Wu, Vincent M., Tantiongloc, Justin C., Kang, Dae Y., Coleman, Todd P., Baxter, Sally L., Weinreb, Robert N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248824/
https://www.ncbi.nlm.nih.gov/pubmed/32366013
http://dx.doi.org/10.3390/s20092570
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author Aguilar-Rivera, Marcelo
Erudaitius, Dieanira T.
Wu, Vincent M.
Tantiongloc, Justin C.
Kang, Dae Y.
Coleman, Todd P.
Baxter, Sally L.
Weinreb, Robert N.
author_facet Aguilar-Rivera, Marcelo
Erudaitius, Dieanira T.
Wu, Vincent M.
Tantiongloc, Justin C.
Kang, Dae Y.
Coleman, Todd P.
Baxter, Sally L.
Weinreb, Robert N.
author_sort Aguilar-Rivera, Marcelo
collection PubMed
description Glaucoma, the leading cause of irreversible blindness, affects >70 million people worldwide. Lowering intraocular pressure via topical administration of eye drops is the most common first-line therapy for glaucoma. This treatment paradigm has notoriously high non-adherence rates: ranging from 30% to 80%. The advent of smart phone enabled technologies creates promise for improving eyedrop adherence. However, previous eyedrop electronic monitoring solutions had awkward medication bottle adjuncts and crude software for monitoring the administration of a drop that adversely affected their ability to foster sustainable improvements in adherence. The current work begins to address this unmet need for wireless technology by creating a “smart drop” bottle. This medication bottle is instrumented with sensing electronics that enable detection of each eyedrop administered while maintaining the shape and size of the bottle. This is achieved by a thin electronic force sensor wrapped around the bottle and underneath the label, interfaced with a thin electronic circuit underneath the bottle that allows for detection and wireless transmission to a smart-phone application. We demonstrate 100% success rate of wireless communication over 75 feet with <1% false positive and false negative rates of single drop deliveries, thus providing a viable solution for eyedrop monitoring for glaucoma patients.
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spelling pubmed-72488242020-06-10 Smart Electronic Eyedrop Bottle for Unobtrusive Monitoring of Glaucoma Medication Adherence Aguilar-Rivera, Marcelo Erudaitius, Dieanira T. Wu, Vincent M. Tantiongloc, Justin C. Kang, Dae Y. Coleman, Todd P. Baxter, Sally L. Weinreb, Robert N. Sensors (Basel) Article Glaucoma, the leading cause of irreversible blindness, affects >70 million people worldwide. Lowering intraocular pressure via topical administration of eye drops is the most common first-line therapy for glaucoma. This treatment paradigm has notoriously high non-adherence rates: ranging from 30% to 80%. The advent of smart phone enabled technologies creates promise for improving eyedrop adherence. However, previous eyedrop electronic monitoring solutions had awkward medication bottle adjuncts and crude software for monitoring the administration of a drop that adversely affected their ability to foster sustainable improvements in adherence. The current work begins to address this unmet need for wireless technology by creating a “smart drop” bottle. This medication bottle is instrumented with sensing electronics that enable detection of each eyedrop administered while maintaining the shape and size of the bottle. This is achieved by a thin electronic force sensor wrapped around the bottle and underneath the label, interfaced with a thin electronic circuit underneath the bottle that allows for detection and wireless transmission to a smart-phone application. We demonstrate 100% success rate of wireless communication over 75 feet with <1% false positive and false negative rates of single drop deliveries, thus providing a viable solution for eyedrop monitoring for glaucoma patients. MDPI 2020-04-30 /pmc/articles/PMC7248824/ /pubmed/32366013 http://dx.doi.org/10.3390/s20092570 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aguilar-Rivera, Marcelo
Erudaitius, Dieanira T.
Wu, Vincent M.
Tantiongloc, Justin C.
Kang, Dae Y.
Coleman, Todd P.
Baxter, Sally L.
Weinreb, Robert N.
Smart Electronic Eyedrop Bottle for Unobtrusive Monitoring of Glaucoma Medication Adherence
title Smart Electronic Eyedrop Bottle for Unobtrusive Monitoring of Glaucoma Medication Adherence
title_full Smart Electronic Eyedrop Bottle for Unobtrusive Monitoring of Glaucoma Medication Adherence
title_fullStr Smart Electronic Eyedrop Bottle for Unobtrusive Monitoring of Glaucoma Medication Adherence
title_full_unstemmed Smart Electronic Eyedrop Bottle for Unobtrusive Monitoring of Glaucoma Medication Adherence
title_short Smart Electronic Eyedrop Bottle for Unobtrusive Monitoring of Glaucoma Medication Adherence
title_sort smart electronic eyedrop bottle for unobtrusive monitoring of glaucoma medication adherence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248824/
https://www.ncbi.nlm.nih.gov/pubmed/32366013
http://dx.doi.org/10.3390/s20092570
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