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Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials

The present study reports on the encapsulation of Elsholtzia ciliata ethanolic extract by freeze-drying method using skim milk, sodium caseinate, gum Arabic, maltodextrin, beta-maltodextrin, and resistant-maltodextrin alone or in mixtures of two or four encapsulants. The encapsulation ability of the...

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Autores principales: Pudziuvelyte, Lauryna, Marksa, Mindaugas, Sosnowska, Katarzyna, Winnicka, Katarzyna, Morkuniene, Ramune, Bernatoniene, Jurga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248874/
https://www.ncbi.nlm.nih.gov/pubmed/32397476
http://dx.doi.org/10.3390/molecules25092237
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author Pudziuvelyte, Lauryna
Marksa, Mindaugas
Sosnowska, Katarzyna
Winnicka, Katarzyna
Morkuniene, Ramune
Bernatoniene, Jurga
author_facet Pudziuvelyte, Lauryna
Marksa, Mindaugas
Sosnowska, Katarzyna
Winnicka, Katarzyna
Morkuniene, Ramune
Bernatoniene, Jurga
author_sort Pudziuvelyte, Lauryna
collection PubMed
description The present study reports on the encapsulation of Elsholtzia ciliata ethanolic extract by freeze-drying method using skim milk, sodium caseinate, gum Arabic, maltodextrin, beta-maltodextrin, and resistant-maltodextrin alone or in mixtures of two or four encapsulants. The encapsulation ability of the final mixtures was evaluated based on their microencapsulating efficiency (EE) of total phenolic compounds (TPC) and the physicochemical properties of freeze-dried powders. Results showed that the freeze-dried powders produced using two encapsulants have a lower moisture content, but higher solubility, Carr index, and Hausner ratio than freeze-dried powders produced using only one encapsulant in the formulation. The microencapsulating efficiency of TPC also varied depending on encapsulants used. The lowest EE% of TPC was determined with maltodextrin (21.17%), and the highest with sodium caseinate (83.02%). Scanning electron microscopy revealed that freeze-drying resulted in the formation of different size, irregular shape glassy particles. This study demonstrated good mucoadhesive properties of freeze-dried powders, which could be incorporated in buccal or oral delivery dosage forms. In conclusion, the microencapsulation of E. ciliata ethanolic extract by freeze-drying is an effective method to produce new value-added pharmaceutical or food formulations with polyphenols.
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spelling pubmed-72488742020-06-10 Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials Pudziuvelyte, Lauryna Marksa, Mindaugas Sosnowska, Katarzyna Winnicka, Katarzyna Morkuniene, Ramune Bernatoniene, Jurga Molecules Article The present study reports on the encapsulation of Elsholtzia ciliata ethanolic extract by freeze-drying method using skim milk, sodium caseinate, gum Arabic, maltodextrin, beta-maltodextrin, and resistant-maltodextrin alone or in mixtures of two or four encapsulants. The encapsulation ability of the final mixtures was evaluated based on their microencapsulating efficiency (EE) of total phenolic compounds (TPC) and the physicochemical properties of freeze-dried powders. Results showed that the freeze-dried powders produced using two encapsulants have a lower moisture content, but higher solubility, Carr index, and Hausner ratio than freeze-dried powders produced using only one encapsulant in the formulation. The microencapsulating efficiency of TPC also varied depending on encapsulants used. The lowest EE% of TPC was determined with maltodextrin (21.17%), and the highest with sodium caseinate (83.02%). Scanning electron microscopy revealed that freeze-drying resulted in the formation of different size, irregular shape glassy particles. This study demonstrated good mucoadhesive properties of freeze-dried powders, which could be incorporated in buccal or oral delivery dosage forms. In conclusion, the microencapsulation of E. ciliata ethanolic extract by freeze-drying is an effective method to produce new value-added pharmaceutical or food formulations with polyphenols. MDPI 2020-05-09 /pmc/articles/PMC7248874/ /pubmed/32397476 http://dx.doi.org/10.3390/molecules25092237 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pudziuvelyte, Lauryna
Marksa, Mindaugas
Sosnowska, Katarzyna
Winnicka, Katarzyna
Morkuniene, Ramune
Bernatoniene, Jurga
Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials
title Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials
title_full Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials
title_fullStr Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials
title_full_unstemmed Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials
title_short Freeze-Drying Technique for Microencapsulation of Elsholtzia ciliata Ethanolic Extract Using Different Coating Materials
title_sort freeze-drying technique for microencapsulation of elsholtzia ciliata ethanolic extract using different coating materials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248874/
https://www.ncbi.nlm.nih.gov/pubmed/32397476
http://dx.doi.org/10.3390/molecules25092237
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