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Identification of Transient Receptor Potential Vanilloid 3 Antagonists from Achillea alpina L. and Separation by Liquid-Liquid-Refining Extraction and High-Speed Counter-Current Chromatography

Bioassay-guided fractionation of the ethanol extract of whole herbs of Achillea alpina led to the isolation of isochlorogenic acids A and B as transient receptor potential vanilloid 3 (TRPV3) channel antagonists by using a calcium fluorescent assay. The structures were identified by spectroscopic an...

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Detalles Bibliográficos
Autores principales:	Sun, Shi-Wei, Wang, Rong-Rong, Sun, Xiao-Ying, Fan, Jia-He, Qi, Hang, Liu, Yang, Qin, Guo-Qing, Wang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248954/ https://www.ncbi.nlm.nih.gov/pubmed/32357572 http://dx.doi.org/10.3390/molecules25092025

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