Conjugate Addition of Grignard Reagents to Thiochromones Catalyzed by Copper Salts: A Unified Approach to Both 2-Alkylthiochroman-4-One and Thioflavanone

Grignard reagents undergo conjugate addition to thiochromones catalyzed by copper salts to afford 2-substituted-thiochroman-4-ones, both 2-alkylthiochroman-4-ones and thioflavanones (2-arylthiochroman-4-ones), in good yields with trimethylsilyl chloride (TMSCl) as an additive. The best yields of 1,4...

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Detalles Bibliográficos
Autores principales: Bellinger, Tania J., Harvin, Teavian, Pickens-Flynn, Ti’Bran, Austin, Nataleigh, Whitaker, Samuel H., Tang Yuk Tutein, Mai Ling C., Hukins, Dabria T., Deese, Nichele, Guo, Fenghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248974/
https://www.ncbi.nlm.nih.gov/pubmed/32370080
http://dx.doi.org/10.3390/molecules25092128

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