Dysregulation of type I interferon responses in COVID-19

Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted. Here, we discuss how imbalanced interferon responses may contribute to the pathology of COVID-19.

Detalles Bibliográficos
Autores principales: Acharya, Dhiraj, Liu, GuanQun, Gack, Michaela U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249038/
https://www.ncbi.nlm.nih.gov/pubmed/32457522
http://dx.doi.org/10.1038/s41577-020-0346-x
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author Acharya, Dhiraj
Liu, GuanQun
Gack, Michaela U.
author_facet Acharya, Dhiraj
Liu, GuanQun
Gack, Michaela U.
author_sort Acharya, Dhiraj
collection PubMed
description Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted. Here, we discuss how imbalanced interferon responses may contribute to the pathology of COVID-19.
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spelling pubmed-72490382020-05-26 Dysregulation of type I interferon responses in COVID-19 Acharya, Dhiraj Liu, GuanQun Gack, Michaela U. Nat Rev Immunol Comment Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted. Here, we discuss how imbalanced interferon responses may contribute to the pathology of COVID-19. Nature Publishing Group UK 2020-05-26 2020 /pmc/articles/PMC7249038/ /pubmed/32457522 http://dx.doi.org/10.1038/s41577-020-0346-x Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Acharya, Dhiraj
Liu, GuanQun
Gack, Michaela U.
Dysregulation of type I interferon responses in COVID-19
title Dysregulation of type I interferon responses in COVID-19
title_full Dysregulation of type I interferon responses in COVID-19
title_fullStr Dysregulation of type I interferon responses in COVID-19
title_full_unstemmed Dysregulation of type I interferon responses in COVID-19
title_short Dysregulation of type I interferon responses in COVID-19
title_sort dysregulation of type i interferon responses in covid-19
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249038/
https://www.ncbi.nlm.nih.gov/pubmed/32457522
http://dx.doi.org/10.1038/s41577-020-0346-x
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