A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isa...

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Detalles Bibliográficos
Autores principales: Gambacorta, Guido, Apperley, David C., Baxendale, Ian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249113/
https://www.ncbi.nlm.nih.gov/pubmed/32380725
http://dx.doi.org/10.3390/molecules25092160
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author Gambacorta, Guido
Apperley, David C.
Baxendale, Ian R.
author_facet Gambacorta, Guido
Apperley, David C.
Baxendale, Ian R.
author_sort Gambacorta, Guido
collection PubMed
description The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.
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spelling pubmed-72491132020-06-10 A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives Gambacorta, Guido Apperley, David C. Baxendale, Ian R. Molecules Article The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation. MDPI 2020-05-05 /pmc/articles/PMC7249113/ /pubmed/32380725 http://dx.doi.org/10.3390/molecules25092160 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gambacorta, Guido
Apperley, David C.
Baxendale, Ian R.
A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
title A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
title_full A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
title_fullStr A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
title_full_unstemmed A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
title_short A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
title_sort one-pot divergent sequence to pyrazole and quinoline derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249113/
https://www.ncbi.nlm.nih.gov/pubmed/32380725
http://dx.doi.org/10.3390/molecules25092160
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