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Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications

Discovering new materials to aid in the therapeutic delivery of drugs is in high demand. PLGA, a FDA approved polymer, is well known in the literature to form films or nanoparticles that can load, protect, and deliver drug molecules; however, its incompatibility with certain drugs (due to hydrophili...

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Autores principales: Duskey, Jason Thomas, Baraldi, Cecilia, Gamberini, Maria Cristina, Ottonelli, Ilaria, Da Ros, Federica, Tosi, Giovanni, Forni, Flavio, Vandelli, Maria Angela, Ruozi, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249265/
https://www.ncbi.nlm.nih.gov/pubmed/32260469
http://dx.doi.org/10.3390/polym12040823
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author Duskey, Jason Thomas
Baraldi, Cecilia
Gamberini, Maria Cristina
Ottonelli, Ilaria
Da Ros, Federica
Tosi, Giovanni
Forni, Flavio
Vandelli, Maria Angela
Ruozi, Barbara
author_facet Duskey, Jason Thomas
Baraldi, Cecilia
Gamberini, Maria Cristina
Ottonelli, Ilaria
Da Ros, Federica
Tosi, Giovanni
Forni, Flavio
Vandelli, Maria Angela
Ruozi, Barbara
author_sort Duskey, Jason Thomas
collection PubMed
description Discovering new materials to aid in the therapeutic delivery of drugs is in high demand. PLGA, a FDA approved polymer, is well known in the literature to form films or nanoparticles that can load, protect, and deliver drug molecules; however, its incompatibility with certain drugs (due to hydrophilicity or charge repulsion interactions) limits its use. Combining PLGA or other polymers such as polycaprolactone with other safe and positively-charged molecules, such as chitosan, has been sought after to make hybrid systems that are more flexible in terms of loading ability, but often the reactions for polymer coupling use harsh conditions, films, unpurified products, or create a single unoptimized product. In this work, we aimed to investigate possible innovative improvements regarding two synthetic procedures. Two methods were attempted and analytically compared using nuclear magnetic resonance (NMR), fourier-transform infrared spectroscopy (FT-IR), and dynamic scanning calorimetry (DSC) to furnish pure, homogenous, and tunable PLGA-chitosan hybrid polymers. These were fully characterized by analytical methods. A series of hybrids was produced that could be used to increase the suitability of PLGA with previously non-compatible drug molecules.
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spelling pubmed-72492652020-06-10 Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications Duskey, Jason Thomas Baraldi, Cecilia Gamberini, Maria Cristina Ottonelli, Ilaria Da Ros, Federica Tosi, Giovanni Forni, Flavio Vandelli, Maria Angela Ruozi, Barbara Polymers (Basel) Article Discovering new materials to aid in the therapeutic delivery of drugs is in high demand. PLGA, a FDA approved polymer, is well known in the literature to form films or nanoparticles that can load, protect, and deliver drug molecules; however, its incompatibility with certain drugs (due to hydrophilicity or charge repulsion interactions) limits its use. Combining PLGA or other polymers such as polycaprolactone with other safe and positively-charged molecules, such as chitosan, has been sought after to make hybrid systems that are more flexible in terms of loading ability, but often the reactions for polymer coupling use harsh conditions, films, unpurified products, or create a single unoptimized product. In this work, we aimed to investigate possible innovative improvements regarding two synthetic procedures. Two methods were attempted and analytically compared using nuclear magnetic resonance (NMR), fourier-transform infrared spectroscopy (FT-IR), and dynamic scanning calorimetry (DSC) to furnish pure, homogenous, and tunable PLGA-chitosan hybrid polymers. These were fully characterized by analytical methods. A series of hybrids was produced that could be used to increase the suitability of PLGA with previously non-compatible drug molecules. MDPI 2020-04-04 /pmc/articles/PMC7249265/ /pubmed/32260469 http://dx.doi.org/10.3390/polym12040823 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Duskey, Jason Thomas
Baraldi, Cecilia
Gamberini, Maria Cristina
Ottonelli, Ilaria
Da Ros, Federica
Tosi, Giovanni
Forni, Flavio
Vandelli, Maria Angela
Ruozi, Barbara
Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications
title Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications
title_full Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications
title_fullStr Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications
title_full_unstemmed Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications
title_short Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications
title_sort investigating novel syntheses of a series of unique hybrid plga-chitosan polymers for potential therapeutic delivery applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249265/
https://www.ncbi.nlm.nih.gov/pubmed/32260469
http://dx.doi.org/10.3390/polym12040823
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