Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy

BACKGROUND: Detailed structural knowledge of enzyme-inhibitor complexes trapped in intermediate state is the key for a fundamental understanding of reaction mechanisms taking place in enzymes and is indispensable as a structure-guided drug design tool. Solution state NMR uniquely allows the study of...

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Detalles Bibliográficos
Autores principales: Agback, Peter, Woestenenk, Esmeralda, Agback, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249419/
https://www.ncbi.nlm.nih.gov/pubmed/32450796
http://dx.doi.org/10.1186/s12860-020-00283-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249419/
https://www.ncbi.nlm.nih.gov/pubmed/32450796
http://dx.doi.org/10.1186/s12860-020-00283-0

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