Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis

Cardiac amyloidosis is an increasingly recognized cause of heart failure. It remains underdiagnosed despite a significant morbidity and mortality rate. The mean survival in patients with cardiac amyloidosis is less than 1 year in untreated primary light-chain amyloidosis and less than 4 years in wil...

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Autores principales: Abe, Temidayo, Chang, Eric Y, De Allie, Gabrielle, Ajose, Taiwo, Nwokike, Chukwuemeka, Bakinde, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249551/
https://www.ncbi.nlm.nih.gov/pubmed/32547758
http://dx.doi.org/10.1177/2050313X20923259
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author Abe, Temidayo
Chang, Eric Y
De Allie, Gabrielle
Ajose, Taiwo
Nwokike, Chukwuemeka
Bakinde, Nicolas
author_facet Abe, Temidayo
Chang, Eric Y
De Allie, Gabrielle
Ajose, Taiwo
Nwokike, Chukwuemeka
Bakinde, Nicolas
author_sort Abe, Temidayo
collection PubMed
description Cardiac amyloidosis is an increasingly recognized cause of heart failure. It remains underdiagnosed despite a significant morbidity and mortality rate. The mean survival in patients with cardiac amyloidosis is less than 1 year in untreated primary light-chain amyloidosis and less than 4 years in wild-type transthyretin amyloidosis. We report a unique case of a 78-year-old male with transthyretin cardiac amyloidosis, who presented with persistently elevated troponin and progressive heart failure unresponsive to conventional therapy. With this case, we would like to highlight the role of cardiac biomarkers in the early diagnosis of cardiac amyloidosis.
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spelling pubmed-72495512020-06-15 Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis Abe, Temidayo Chang, Eric Y De Allie, Gabrielle Ajose, Taiwo Nwokike, Chukwuemeka Bakinde, Nicolas SAGE Open Med Case Rep Case Report Cardiac amyloidosis is an increasingly recognized cause of heart failure. It remains underdiagnosed despite a significant morbidity and mortality rate. The mean survival in patients with cardiac amyloidosis is less than 1 year in untreated primary light-chain amyloidosis and less than 4 years in wild-type transthyretin amyloidosis. We report a unique case of a 78-year-old male with transthyretin cardiac amyloidosis, who presented with persistently elevated troponin and progressive heart failure unresponsive to conventional therapy. With this case, we would like to highlight the role of cardiac biomarkers in the early diagnosis of cardiac amyloidosis. SAGE Publications 2020-05-20 /pmc/articles/PMC7249551/ /pubmed/32547758 http://dx.doi.org/10.1177/2050313X20923259 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Abe, Temidayo
Chang, Eric Y
De Allie, Gabrielle
Ajose, Taiwo
Nwokike, Chukwuemeka
Bakinde, Nicolas
Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis
title Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis
title_full Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis
title_fullStr Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis
title_full_unstemmed Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis
title_short Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis
title_sort rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249551/
https://www.ncbi.nlm.nih.gov/pubmed/32547758
http://dx.doi.org/10.1177/2050313X20923259
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