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Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
Sodium bicarbonate, commonly known as baking soda, is widely used in the clinic as an antacid for treating gastric hyperacidity, among other conditions. Chao et al have reported a clinical trial about targeting intratumor lactic acidosis–transarterial chemoembolization. Based on conventional transar...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249593/ https://www.ncbi.nlm.nih.gov/pubmed/32448009 http://dx.doi.org/10.1177/1534735420922579 |
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author | Yang, Mengyuan Zhong, Xian Yuan, Ying |
author_facet | Yang, Mengyuan Zhong, Xian Yuan, Ying |
author_sort | Yang, Mengyuan |
collection | PubMed |
description | Sodium bicarbonate, commonly known as baking soda, is widely used in the clinic as an antacid for treating gastric hyperacidity, among other conditions. Chao et al have reported a clinical trial about targeting intratumor lactic acidosis–transarterial chemoembolization. Based on conventional transarterial chemoembolization, the authors added a 5% sodium bicarbonate solution to cytotoxic drugs, resulting in a high local control rate. The explanation for the antitumor effects of sodium bicarbonate is related to acidosis in the tumor microenvironment. In this review, we summarize the findings from studies administering sodium bicarbonate alone or in combination with other anticancer therapies as cancer treatments, and discuss methods for safe and effective use of sodium bicarbonate in the clinic. |
format | Online Article Text |
id | pubmed-7249593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-72495932020-06-15 Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review Yang, Mengyuan Zhong, Xian Yuan, Ying Integr Cancer Ther Review Article Sodium bicarbonate, commonly known as baking soda, is widely used in the clinic as an antacid for treating gastric hyperacidity, among other conditions. Chao et al have reported a clinical trial about targeting intratumor lactic acidosis–transarterial chemoembolization. Based on conventional transarterial chemoembolization, the authors added a 5% sodium bicarbonate solution to cytotoxic drugs, resulting in a high local control rate. The explanation for the antitumor effects of sodium bicarbonate is related to acidosis in the tumor microenvironment. In this review, we summarize the findings from studies administering sodium bicarbonate alone or in combination with other anticancer therapies as cancer treatments, and discuss methods for safe and effective use of sodium bicarbonate in the clinic. SAGE Publications 2020-05-23 /pmc/articles/PMC7249593/ /pubmed/32448009 http://dx.doi.org/10.1177/1534735420922579 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Article Yang, Mengyuan Zhong, Xian Yuan, Ying Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review |
title | Does Baking Soda Function as a Magic Bullet for Patients With Cancer?
A Mini Review |
title_full | Does Baking Soda Function as a Magic Bullet for Patients With Cancer?
A Mini Review |
title_fullStr | Does Baking Soda Function as a Magic Bullet for Patients With Cancer?
A Mini Review |
title_full_unstemmed | Does Baking Soda Function as a Magic Bullet for Patients With Cancer?
A Mini Review |
title_short | Does Baking Soda Function as a Magic Bullet for Patients With Cancer?
A Mini Review |
title_sort | does baking soda function as a magic bullet for patients with cancer?
a mini review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249593/ https://www.ncbi.nlm.nih.gov/pubmed/32448009 http://dx.doi.org/10.1177/1534735420922579 |
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