Cargando…

Independence of HIF1a and androgen signaling pathways in prostate cancer

BACKGROUND: Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progression to castrate-resistant prostate cancer (CRPC). Hypoxia and HIF1a have been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tran, Maxine G. B., Bibby, Becky A. S., Yang, Lingjian, Lo, Franklin, Warren, Anne Y., Shukla, Deepa, Osborne, Michelle, Hadfield, James, Carroll, Thomas, Stark, Rory, Scott, Helen, Ramos-Montoya, Antonio, Massie, Charlie, Maxwell, Patrick, West, Catharine M. L., Mills, Ian G., Neal, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249645/ https://www.ncbi.nlm.nih.gov/pubmed/32450824 http://dx.doi.org/10.1186/s12885-020-06890-6

Ejemplares similares

The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer
por: Sharma, Naomi L., et al.
Publicado: (2014)

New androgen receptor genomic targets show an interaction with the ETS1 transcription factor
por: Massie, Charles E, et al.
Publicado: (2007)

Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer
por: Bibby, Becky A. S., et al.
Publicado: (2021)

The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer
por: Shaw, Greg L., et al.
Publicado: (2016)

HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
por: Mowat, Freya M., et al.
Publicado: (2010)

Technical development and validation of a clinically applicable microenvironment classifier as a biomarker of tumour hypoxia for soft tissue sarcoma
por: Forker, Laura J., et al.
Publicado: (2023)

A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer
por: Warren, Anne Y., et al.
Publicado: (2018)

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts
por: Schietke, Ruth E., et al.
Publicado: (2012)

Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target
por: Asim, Mohammad, et al.
Publicado: (2015)

Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells
por: Jurmeister, Sarah, et al.
Publicado: (2014)

Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts
por: Yang, Lingjian, et al.
Publicado: (2017)

Correction: Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts
por: Yang, Lingjian, et al.
Publicado: (2019)

MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β
por: Cao, Paul, et al.
Publicado: (2010)

Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer
por: Zecchini, Vincent, et al.
Publicado: (2014)

Pro-neural transcription factors as cancer markers
por: Vias, Maria, et al.
Publicado: (2008)

Selection of endogenous control genes for normalising gene expression data derived from formalin-fixed paraffin-embedded tumour tissue
por: Smith, Tim A. D., et al.
Publicado: (2020)

MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma
por: Bibby, Becky A. S., et al.
Publicado: (2015)

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
por: Asim, Mohammad, et al.
Publicado: (2017)

Androgen receptor expression reduces stemness characteristics of prostate cancer cells (PC3) by repression of CD44 and SOX2
por: Srinivasan, Deepa, et al.
Publicado: (2018)

Bidirectional Modulation of HIF-2 Activity through Chemical Ligands
por: Wu, Dalei, et al.
Publicado: (2019)

GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility
por: Theodorou, Vasiliki, et al.
Publicado: (2013)

Renal Hypertrophy in Mice Receiving Estrogens and Androgens
por: Pfeiffer, Carroll A., et al.
Publicado: (1940)

A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy
por: Pertega‐Gomes, Nelma, et al.
Publicado: (2015)

N-Linked Glycosylation Supports Cross-Talk between Receptor Tyrosine Kinases and Androgen Receptor
por: Itkonen, Harri M., et al.
Publicado: (2013)

The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens
por: Mills, Edouard G, et al.
Publicado: (2021)

Androgen Receptor Drives Cellular Senescence
por: Mirochnik, Yelena, et al.
Publicado: (2012)

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer
por: Yang, Lingjian, et al.
Publicado: (2018)

Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype
por: Robinson, Jessica L.L., et al.
Publicado: (2013)

Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy
por: Chen, Jia-Feng, et al.
Publicado: (2019)

Silencing microRNA-330-5p increases MMP1 expression and promotes an invasive phenotype in oesophageal adenocarcinoma
por: Bibby, Becky A. S., et al.
Publicado: (2019)

Secretion of Androgen by the Sparrow Ovary Following Stimulation with Pregnant Mare Serum
por: Pfeiffer, Carroll A., et al.
Publicado: (1941)

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis
por: Khan, M N, et al.
Publicado: (2011)

Regulation of expression of Na(+),K(+)-ATPase in androgen-dependent and androgen-independent prostate cancer
por: Blok, L J, et al.
Publicado: (1999)

Androgen regulation of the androgen receptor coregulators
por: Urbanucci, Alfonso, et al.
Publicado: (2008)

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
por: Vukovic, Milica, et al.
Publicado: (2015)

Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens
por: Dart, D. A., et al.
Publicado: (2011)

The androgen receptor messenger RNA: what do we know?
por: Likos, Eviania, et al.
Publicado: (2022)

Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome
por: Villagomez, Daniel A.F., et al.
Publicado: (2020)

HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network
por: Ramos-Montoya, Antonio, et al.
Publicado: (2014)

Androgen Deprivation-Induced Senescence Promotes Outgrowth of Androgen-Refractory Prostate Cancer Cells
por: Burton, Dominick G. A., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_lvd367oiippdpbm43s66rebe9i