Diagnosis of the accurate genotype of HKαα carriers in patients with thalassemia using multiplex ligation-dependent probe amplification combined with nested polymerase chain reaction

BACKGROUND: Patients carrying the HongKongαα (HKαα) allele and -α(3.7)/ααα(anti-4.2) could be misdiagnosed as -α(3.7)/αα by the current conventional thalassemia detection methods, leading to inaccurate genetic counseling and an incorrect prenatal diagnosis. This study was aimed to accurately analyze...

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Detalles Bibliográficos
Autores principales: Chen, Dong-Mei, Ma, Shi, Tang, Xiang-Lan, Yang, Ji-Yun, Yang, Zheng-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249720/
https://www.ncbi.nlm.nih.gov/pubmed/32433049
http://dx.doi.org/10.1097/CM9.0000000000000768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249720/
https://www.ncbi.nlm.nih.gov/pubmed/32433049
http://dx.doi.org/10.1097/CM9.0000000000000768

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