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Diagnosis of the accurate genotype of HKαα carriers in patients with thalassemia using multiplex ligation-dependent probe amplification combined with nested polymerase chain reaction
BACKGROUND: Patients carrying the HongKongαα (HKαα) allele and -α(3.7)/ααα(anti-4.2) could be misdiagnosed as -α(3.7)/αα by the current conventional thalassemia detection methods, leading to inaccurate genetic counseling and an incorrect prenatal diagnosis. This study was aimed to accurately analyze...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wolters Kluwer Health
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249720/ https://www.ncbi.nlm.nih.gov/pubmed/32433049 http://dx.doi.org/10.1097/CM9.0000000000000768 |