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Conical ring array detector for large depth of field photoacoustic macroscopy

Photoacoustic microscopy and macroscopy (PAM) using focused detector scanning are emerging imaging methods for biological tissue, providing high resolution and high sensitivity for structures with optical absorption contrast. However, achieving a constant lateral resolution over a large depth of fie...

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Detalles Bibliográficos
Autores principales: Torke, Paul R., Nuster, Robert, Paltauf, Guenther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249821/
https://www.ncbi.nlm.nih.gov/pubmed/32499937
http://dx.doi.org/10.1364/BOE.386585
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author Torke, Paul R.
Nuster, Robert
Paltauf, Guenther
author_facet Torke, Paul R.
Nuster, Robert
Paltauf, Guenther
author_sort Torke, Paul R.
collection PubMed
description Photoacoustic microscopy and macroscopy (PAM) using focused detector scanning are emerging imaging methods for biological tissue, providing high resolution and high sensitivity for structures with optical absorption contrast. However, achieving a constant lateral resolution over a large depth of field for deeply penetrating photoacoustic macroscopy is still a challenge. In this work, a detector design for scanning photoacoustic macroscopy is presented. Based on simulation results, a sensor array geometry is developed and fabricated that consists of concentric ring elements made of polyvinylidene fluoride (PVDF) film in a geometry that combines a centered planar ring with several inclined outer ring elements. The reconstruction algorithm, which uses dynamic focusing and coherence weighting, is explained and its capability to reduce artefacts occurring for single element conical sensors is demonstrated. Several phantoms are manufactured to evaluate the performance of the array in experimental measurements. The sensor array provides a constant axial and lateral resolution of 95 µm and 285 µm, respectively, over a depth of field of 20 mm. The depth of field corresponds approximately to the maximum imaging depth in biological tissue, estimated from the sensitivity of the array. With its ability to achieve the maximum resolution even with a very small scanning range, the array is believed to have applications in the imaging of limited regions of interest buried in biological tissue.
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spelling pubmed-72498212020-06-03 Conical ring array detector for large depth of field photoacoustic macroscopy Torke, Paul R. Nuster, Robert Paltauf, Guenther Biomed Opt Express Article Photoacoustic microscopy and macroscopy (PAM) using focused detector scanning are emerging imaging methods for biological tissue, providing high resolution and high sensitivity for structures with optical absorption contrast. However, achieving a constant lateral resolution over a large depth of field for deeply penetrating photoacoustic macroscopy is still a challenge. In this work, a detector design for scanning photoacoustic macroscopy is presented. Based on simulation results, a sensor array geometry is developed and fabricated that consists of concentric ring elements made of polyvinylidene fluoride (PVDF) film in a geometry that combines a centered planar ring with several inclined outer ring elements. The reconstruction algorithm, which uses dynamic focusing and coherence weighting, is explained and its capability to reduce artefacts occurring for single element conical sensors is demonstrated. Several phantoms are manufactured to evaluate the performance of the array in experimental measurements. The sensor array provides a constant axial and lateral resolution of 95 µm and 285 µm, respectively, over a depth of field of 20 mm. The depth of field corresponds approximately to the maximum imaging depth in biological tissue, estimated from the sensitivity of the array. With its ability to achieve the maximum resolution even with a very small scanning range, the array is believed to have applications in the imaging of limited regions of interest buried in biological tissue. Optical Society of America 2020-04-09 /pmc/articles/PMC7249821/ /pubmed/32499937 http://dx.doi.org/10.1364/BOE.386585 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
spellingShingle Article
Torke, Paul R.
Nuster, Robert
Paltauf, Guenther
Conical ring array detector for large depth of field photoacoustic macroscopy
title Conical ring array detector for large depth of field photoacoustic macroscopy
title_full Conical ring array detector for large depth of field photoacoustic macroscopy
title_fullStr Conical ring array detector for large depth of field photoacoustic macroscopy
title_full_unstemmed Conical ring array detector for large depth of field photoacoustic macroscopy
title_short Conical ring array detector for large depth of field photoacoustic macroscopy
title_sort conical ring array detector for large depth of field photoacoustic macroscopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249821/
https://www.ncbi.nlm.nih.gov/pubmed/32499937
http://dx.doi.org/10.1364/BOE.386585
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