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Successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: A case report

RATIONALE: Idarucizumab is a specific reversal agent for patients with bleeding related to the anticoagulant dabigatran. There are no prior descriptions of Idarucizumab administration in the prehospital setting for intracranial hemorrhage. PATIENT CONCERNS: An 82-year-old woman treated with dabigatr...

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Autores principales: Thirunavukkarasu, Sibi, Kalashyan, Hayrapet, Jickling, Glen, Jeerakathil, Thomas Joseph, Jayaprakash, Harsha Kamble, Buck, Brian H., Shuaib, Ashfaq, Butcher, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249931/
https://www.ncbi.nlm.nih.gov/pubmed/32481289
http://dx.doi.org/10.1097/MD.0000000000020200
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author Thirunavukkarasu, Sibi
Kalashyan, Hayrapet
Jickling, Glen
Jeerakathil, Thomas Joseph
Jayaprakash, Harsha Kamble
Buck, Brian H.
Shuaib, Ashfaq
Butcher, Ken
author_facet Thirunavukkarasu, Sibi
Kalashyan, Hayrapet
Jickling, Glen
Jeerakathil, Thomas Joseph
Jayaprakash, Harsha Kamble
Buck, Brian H.
Shuaib, Ashfaq
Butcher, Ken
author_sort Thirunavukkarasu, Sibi
collection PubMed
description RATIONALE: Idarucizumab is a specific reversal agent for patients with bleeding related to the anticoagulant dabigatran. There are no prior descriptions of Idarucizumab administration in the prehospital setting for intracranial hemorrhage. PATIENT CONCERNS: An 82-year-old woman treated with dabigatran for atrial fibrillation developed acute focal weakness. This led to activation of emergency medical services and assessment in the mobile stroke unit (MSU). DIAGNOSIS: Computed tomography of the brain performed in the MSU revealed an acute subdural hematoma. INTERVENTIONS: The patient was treated with Idarucizumab in the MSU. OUTCOMES: The subdural hematoma was treated with a burr hole evacuation and the patient was discharged to a rehabilitation facility without residual focal neurological deficits. LESSONS: Idarucizumab can be used safely and effectively to treat dabigatran-associated intracranial hemorrhage in the prehospital setting.
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spelling pubmed-72499312020-06-15 Successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: A case report Thirunavukkarasu, Sibi Kalashyan, Hayrapet Jickling, Glen Jeerakathil, Thomas Joseph Jayaprakash, Harsha Kamble Buck, Brian H. Shuaib, Ashfaq Butcher, Ken Medicine (Baltimore) 5300 RATIONALE: Idarucizumab is a specific reversal agent for patients with bleeding related to the anticoagulant dabigatran. There are no prior descriptions of Idarucizumab administration in the prehospital setting for intracranial hemorrhage. PATIENT CONCERNS: An 82-year-old woman treated with dabigatran for atrial fibrillation developed acute focal weakness. This led to activation of emergency medical services and assessment in the mobile stroke unit (MSU). DIAGNOSIS: Computed tomography of the brain performed in the MSU revealed an acute subdural hematoma. INTERVENTIONS: The patient was treated with Idarucizumab in the MSU. OUTCOMES: The subdural hematoma was treated with a burr hole evacuation and the patient was discharged to a rehabilitation facility without residual focal neurological deficits. LESSONS: Idarucizumab can be used safely and effectively to treat dabigatran-associated intracranial hemorrhage in the prehospital setting. Wolters Kluwer Health 2020-05-22 /pmc/articles/PMC7249931/ /pubmed/32481289 http://dx.doi.org/10.1097/MD.0000000000020200 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5300
Thirunavukkarasu, Sibi
Kalashyan, Hayrapet
Jickling, Glen
Jeerakathil, Thomas Joseph
Jayaprakash, Harsha Kamble
Buck, Brian H.
Shuaib, Ashfaq
Butcher, Ken
Successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: A case report
title Successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: A case report
title_full Successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: A case report
title_fullStr Successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: A case report
title_full_unstemmed Successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: A case report
title_short Successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: A case report
title_sort successful dabigatran reversal after subdural hemorrhage using idarucizumab in a mobile stroke unit: a case report
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249931/
https://www.ncbi.nlm.nih.gov/pubmed/32481289
http://dx.doi.org/10.1097/MD.0000000000020200
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