Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy

No effective treatment for COVID-19 has been well established yet. Nafamostat, known as anticoagulant, has potential anti-inflammatory and anti-viral activities against COVID-19. We report three cases of COVID-19 pneumonia who progressed while using antiviral drugs and needed supplementary oxygen th...

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Autores principales: Jang, Sukbin, Rhee, Ji-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250091/
https://www.ncbi.nlm.nih.gov/pubmed/32470602
http://dx.doi.org/10.1016/j.ijid.2020.05.072
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author Jang, Sukbin
Rhee, Ji-Young
author_facet Jang, Sukbin
Rhee, Ji-Young
author_sort Jang, Sukbin
collection PubMed
description No effective treatment for COVID-19 has been well established yet. Nafamostat, known as anticoagulant, has potential anti-inflammatory and anti-viral activities against COVID-19. We report three cases of COVID-19 pneumonia who progressed while using antiviral drugs and needed supplementary oxygen therapy, improved after treatment with nafamostat. These preliminary findings show the possibility that Nafamostat can be considered to be used in elderly patients with COVID-19 pneumonia who need oxygen therapy. The effectiveness of nafamostat should be evaluated in further studies.
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spelling pubmed-72500912020-05-27 Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy Jang, Sukbin Rhee, Ji-Young Int J Infect Dis Case Report No effective treatment for COVID-19 has been well established yet. Nafamostat, known as anticoagulant, has potential anti-inflammatory and anti-viral activities against COVID-19. We report three cases of COVID-19 pneumonia who progressed while using antiviral drugs and needed supplementary oxygen therapy, improved after treatment with nafamostat. These preliminary findings show the possibility that Nafamostat can be considered to be used in elderly patients with COVID-19 pneumonia who need oxygen therapy. The effectiveness of nafamostat should be evaluated in further studies. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-07 2020-05-26 /pmc/articles/PMC7250091/ /pubmed/32470602 http://dx.doi.org/10.1016/j.ijid.2020.05.072 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Jang, Sukbin
Rhee, Ji-Young
Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy
title Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy
title_full Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy
title_fullStr Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy
title_full_unstemmed Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy
title_short Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy
title_sort three cases of treatment with nafamostat in elderly patients with covid-19 pneumonia who need oxygen therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250091/
https://www.ncbi.nlm.nih.gov/pubmed/32470602
http://dx.doi.org/10.1016/j.ijid.2020.05.072
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