FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer

Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC. Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blo...

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Detalles Bibliográficos
Autores principales: Yang, Ying, Lu, Tingting, Li, Ziming, Lu, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250189/
https://www.ncbi.nlm.nih.gov/pubmed/32380883
http://dx.doi.org/10.1080/19336918.2020.1766308
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author Yang, Ying
Lu, Tingting
Li, Ziming
Lu, Shun
author_facet Yang, Ying
Lu, Tingting
Li, Ziming
Lu, Shun
author_sort Yang, Ying
collection PubMed
description Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC. Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blot. Cell migration and invasion were assessed by transwell assay. Key findings: CCND1 was co-overexpressed with FGFR1 in lung cancer patients. Overexpression of CCND1 promoted LSCC cell proliferation and metastasis. FGFR1 promoted the processes of EMT through AKT/MAPK signaling by targeting CCND1 in FGFR1-amplification cell lines. Significance: IIn conclusion, our study demonstrated the regulatory mechanism between CCND1 and FGFR1 in FGFR1 amplified LSCC. Co-targeting CCND1 and FGFR1 could provide greater clinical benefits.
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spelling pubmed-72501892020-06-03 FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer Yang, Ying Lu, Tingting Li, Ziming Lu, Shun Cell Adh Migr Research Paper Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC. Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blot. Cell migration and invasion were assessed by transwell assay. Key findings: CCND1 was co-overexpressed with FGFR1 in lung cancer patients. Overexpression of CCND1 promoted LSCC cell proliferation and metastasis. FGFR1 promoted the processes of EMT through AKT/MAPK signaling by targeting CCND1 in FGFR1-amplification cell lines. Significance: IIn conclusion, our study demonstrated the regulatory mechanism between CCND1 and FGFR1 in FGFR1 amplified LSCC. Co-targeting CCND1 and FGFR1 could provide greater clinical benefits. Taylor & Francis 2020-05-18 /pmc/articles/PMC7250189/ /pubmed/32380883 http://dx.doi.org/10.1080/19336918.2020.1766308 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Yang, Ying
Lu, Tingting
Li, Ziming
Lu, Shun
FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer
title FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer
title_full FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer
title_fullStr FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer
title_full_unstemmed FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer
title_short FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer
title_sort fgfr1 regulates proliferation and metastasis by targeting ccnd1 in fgfr1 amplified lung cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250189/
https://www.ncbi.nlm.nih.gov/pubmed/32380883
http://dx.doi.org/10.1080/19336918.2020.1766308
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