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Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
PURPOSE: The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational stu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250315/ https://www.ncbi.nlm.nih.gov/pubmed/32547139 http://dx.doi.org/10.2147/DMSO.S248352 |
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author | Chen, Zefeng Bai, Yulan Long, Xinyang Luo, Qianqian Wen, Zheng Li, Yuanfan Huang, Shengzhu Yan, Yunkun Mo, Zengnan |
author_facet | Chen, Zefeng Bai, Yulan Long, Xinyang Luo, Qianqian Wen, Zheng Li, Yuanfan Huang, Shengzhu Yan, Yunkun Mo, Zengnan |
author_sort | Chen, Zefeng |
collection | PubMed |
description | PURPOSE: The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them. MATERIALS AND AND METHODS: Two-sample MR analyses and multiple sensitivity analyses were performed using the summary data from the ADIPOGen consortium, MAGIC Consortium, and a meta-analysis of GWAS with a considerable sample of T2DM (62,892 cases and 596,424 controls of European ancestry). We got eight valid genetic variants to predict the causal effect among adiponectin and T2DM and glucose homeostasis after excluding the probable invalid or pleiotropic variants. RESULTS: Adiponectin was not associated with T2DM (odds ratio (OR) = 1.004; 95% confidence interval (CI): 0.740, 1.363) when using MR Egger after removing the invalid SNPs, and the results were consistent when using the other four methods. Similar results existed among adiponectin and HOMA-β, HOMA-IR, FI, FG. CONCLUSION: Our MR study revealed that adiponectin had no causal effect on T2DM and glucose homeostasis and that the associations among them in observational studies may be due to confounding factors. |
format | Online Article Text |
id | pubmed-7250315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-72503152020-06-15 Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study Chen, Zefeng Bai, Yulan Long, Xinyang Luo, Qianqian Wen, Zheng Li, Yuanfan Huang, Shengzhu Yan, Yunkun Mo, Zengnan Diabetes Metab Syndr Obes Original Research PURPOSE: The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them. MATERIALS AND AND METHODS: Two-sample MR analyses and multiple sensitivity analyses were performed using the summary data from the ADIPOGen consortium, MAGIC Consortium, and a meta-analysis of GWAS with a considerable sample of T2DM (62,892 cases and 596,424 controls of European ancestry). We got eight valid genetic variants to predict the causal effect among adiponectin and T2DM and glucose homeostasis after excluding the probable invalid or pleiotropic variants. RESULTS: Adiponectin was not associated with T2DM (odds ratio (OR) = 1.004; 95% confidence interval (CI): 0.740, 1.363) when using MR Egger after removing the invalid SNPs, and the results were consistent when using the other four methods. Similar results existed among adiponectin and HOMA-β, HOMA-IR, FI, FG. CONCLUSION: Our MR study revealed that adiponectin had no causal effect on T2DM and glucose homeostasis and that the associations among them in observational studies may be due to confounding factors. Dove 2020-05-22 /pmc/articles/PMC7250315/ /pubmed/32547139 http://dx.doi.org/10.2147/DMSO.S248352 Text en © 2020 Chen et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Chen, Zefeng Bai, Yulan Long, Xinyang Luo, Qianqian Wen, Zheng Li, Yuanfan Huang, Shengzhu Yan, Yunkun Mo, Zengnan Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study |
title | Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study |
title_full | Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study |
title_fullStr | Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study |
title_full_unstemmed | Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study |
title_short | Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study |
title_sort | effects of adiponectin on t2dm and glucose homeostasis: a mendelian randomization study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250315/ https://www.ncbi.nlm.nih.gov/pubmed/32547139 http://dx.doi.org/10.2147/DMSO.S248352 |
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