Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness

Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candid...

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Detalles Bibliográficos
Autores principales: Pujhari, Sujit, Rasgon, Jason L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250318/
https://www.ncbi.nlm.nih.gov/pubmed/32434416
http://dx.doi.org/10.1080/21505594.2020.1763637
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author Pujhari, Sujit
Rasgon, Jason L
author_facet Pujhari, Sujit
Rasgon, Jason L
author_sort Pujhari, Sujit
collection PubMed
description Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.
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spelling pubmed-72503182020-06-03 Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness Pujhari, Sujit Rasgon, Jason L Virulence Editorial Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung. Taylor & Francis 2020-05-20 /pmc/articles/PMC7250318/ /pubmed/32434416 http://dx.doi.org/10.1080/21505594.2020.1763637 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial
Pujhari, Sujit
Rasgon, Jason L
Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_full Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_fullStr Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_full_unstemmed Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_short Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
title_sort mice with humanized-lungs and immune system - an idealized model for covid-19 and other respiratory illness
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250318/
https://www.ncbi.nlm.nih.gov/pubmed/32434416
http://dx.doi.org/10.1080/21505594.2020.1763637
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